Endocrine Abstracts

The relationship between subclinical hypothyroidism (SH) and Atherosclerotic (At) cardiovascular diseases (CVD) has been one of the most popular and discussing topics, because the existence of a causal relationship between Hashimoto’s thyroiditis (HT), the lipid profile, and the molecular biology of the follicular epithelium has not been conclusively established. We investigated 59 patients (female), which had undergone total thyroidectomy, lobectomy. Patients were divided into 3 groups: group I – HT (n=22), group II – HT with At (n=12), group III – At (n=25). Thyroid function and lipid profile were determined by international guidelines of laboratory tests, coronary and femoral arteries intima-media thickness (IMT) - high-resolution ultrasonography, histological (H&E) and immunohistochemical markers were used: transcriptional protein p63 and neuroectodermal marker protein S100. The obtained results showed that: dyslipidemia and the diastolic hypertension accelerate the hypothyroidism in II group (HT with At) by predisposing carotid and femoral arteries IMT. FT4 is related to clinical features of atherosclerosis, THS and anti-TPO antibody levels are directly linked to the cardiovascular disease complications (myocardial infarction and hypertension). Biomarkers S100 and p63 data revealed a direct negative correlation between hypercholesterolemia and high morphological risks of Hashimoto’s parenchyma changes. Namely, the trend of follicular epithelial dysplasia changes in the form of remodeling of parenchyma stem cells was revealed.