Endocrine Abstracts

Objective: Coronary heart disease (CHD) is one of the leading causes of death worldwide. According to WHO experts, one out of 4 deaths in the world is due to CHD (17.8 million people annually). Type 2 diabetes is an independent risk factor for CHD. Thrombotic complications of atherosclerosis are the main cause of death in 80% of patients with type 2 diabetes.

Materials and Methods: We studied the prevalence of myocardial infarction in patients with CHD and type 2 diabetes. A cross-sectional controlled study of 50 hospitalized cardialogical patients with chronic CHD was conducted. The main group - patients with chronic CHD and type 2 diabetes, average age was 68.5±9.63 years (women - 44.12%, men - 55.88%). The comparison group was patients with CHD without type 2 diabetes, averageage was 69.5±13.14 years (women – 43.75%, men – 56.25%).

Examination: ECG, НЬА1с, blood chemistry, glucose, heart ultrasound, coronary angiography.

Results: Patients of both groups were comparable in gender, age (U=243,5, P=0,56), laboratory data: cholesterol (4.62 (3.8-5.3) vs 4.78 (3.67-5.67) mmol/l, P=0.7), TG (1.55 (1.21-1.94) vs 1.60 (1.34-2.76) mmol/l, P=0.74), HDL (1.1 (0.9-1.3) vs 1.13 (0.87-1.38) mmol/l, P=0.88), LDL (2.4 (1.9-3.0) vs 3.0 (2.0- 3.7) mmol/l, P=0.12), VLDL (0.58 (0.37-0.72) vs 0.64 (0.54-1.03) mmol/l, P=0, 26), AST (23 (18-40) vs 24 (18-42) U/l, P=0.77), ALT (22 (15.9-41) vs 28 (23-40) U/l, P=0.14), creatinine (102.0 (77.5-144.6) vs 90.3 (75.3-132.9) µmol/l, P=0.47), total protein (71 (66-74) vs 71.35 (66-74) g/l, P=0.89) in blood serum. The blood glucose level in patients of the main group was significantly higher compared to the comparison group (6.8 (5.5-8.5) vs 5.5 (5.2-6.0) mmol/l, P=0.01). HbA1c = 7.7 ± 1.73% in patients of the main group, the experience of type 2 diabetes according to the anamnesis was 8.2 ± 3.14 years. According to the anamnesis data, acute myocardial infarction was diagnosed in 79.41% (n=27) of patients in the main group and in 56.25% (n=9) of patients in the comparison group. The prevalence of a history of myocardial infarction was 23.16% higher in patients of the main group (χ2 = 2.9, P=0.089).

Conclusion: the results of the study indicate an increasing incidence of acute myocardial infarction by 23.16% in patients with coronary heart disease in combination with type 2 diabetes compared to patients with coronary heart disease without type 2 diabetes.