ECE2024 Eposter Presentations Thyroid (198 abstracts)
Thyroid parameters in healthy pregnant women without autoimmune thyroid disease
Violeta Mladenovic 1 , 2 , Sanja Medenica 3 , 4 , Zoran Gluvic 5 , 6 & Milena Mitrovic 7 & 8
1University Clinical Center Kragujevac, Clinic for Endocrinology, Kragujevac, Serbia; 2Faculty of Medical Sciences University of Kragujevac, Internal Medicine, Kragujevac, Serbia; 3Clinical Center of Montenegro, Department of Endocrinology, Internal Medicine Clinic, Clinical Center of Montenegro, Podgorica, Montenegro; 4University of Montenegro, School of Medicine, Podgorica, Montenegro; 5Zemun Clinical Hospital Center, Division of Internal Medicine, Deptartment of Endocrinology, Beograd, Serbia; 6University of Belgrade - Faculty of Medicine, Beograd, Serbia; 7Clinical Center of Vojvodina, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Novi Sad, Serbia; 8Medical Faculty in Novi Sad, Novi Sad, Serbia
Introduction: Pregnancy has a significant effect on the thyroid gland and thyroid function. Thyroid hormone regulates metabolism, growth, and development in most tissues of the body, including various physiological processes. Normal thyroid function is important in order to ensure the best outcome.
Aim: The aim of this study is to analyse values of thyroid parameters during pregnancy in healthy population of pregnant woman.
Matherial and methods: The study included 77 pregnant women in the first trimester registered in Clinic for endocrinology UCC Kragujevac that were tested using OGTT, according to ADA criteria: pregestational and gestational diabetic women were excluded, and also determinaning thyroid parameters (fT4, TSH, TPOAb). The sample size included women in each trimester. We analyzed the values of thyroid parameters in 46 healthy pregnant women (without gestational diabetes mellitus and thyroid disorders including autoimmune thyroiditis). The characteristics of the participants were expressed as mean ± standard deviation.
Results: The mean age of 46 healthy pregnant women was 29.4±4.5 years. The results has been shown in the tables.
| X±SD (95%CI) | 1. trimester | 2. trimester | 3. trimester | After delivery |
| fТ3 ( pg/ml) | 2.67±0.49 (2.53-2.82) | 2.13±0.49 (1.99-2.28) | 2.15±0.45 (2.02-2.29) | 2.44±0.5 (2.29-2.59) |
| fТ4 ( pg/ml) | 10.68±2.16 (10.04-11.32) | 7.58±2.11 (6.96-8.21) | 7.18±1.48 (6.75-7.63) | 10.48±2.27 (9.81-11.16) |
| ТSH(mIU/l) | 2.09±1.11 (1.76-2.42) | 2.59±1.47 (2.16-3.03) | 2.48±1.18 (2.13-2.83) | 1.97±0.89 (1.7-2.24) |
| parameter (min-max) | 1. trimester | 2. trimester | 3. trimester | After delivery |
| fТ3 ( pg/ml) | 1.98-3.16 | 1.64-2.62 | 1.7-2.6 | 1.94-2.94 |
| fТ4 ( pg/ml) | 8.52-12.84 | 5.47-9.69 | 5.7-8.66 | 8.21-13.11 |
| ТSH (mIU/l) | 0.98-3.2 | 1.12-4.06 | 1.3-3.66 | 1.08-2.86 |
Conclusion: This study demonstrates that as the pregnancy progresses, the average values of fT3 and fT4 decrease, and TSH increases, only to return to values similar to before pregnancy after delivery.
Keywords: thyroid parameters, pregnancy
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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