Endocrine Abstracts

Drug-induced liver injury (DILI) today is a global problem in modern gastroenterology and is increasingly common worldwide, demanding focused attention and in-depth study, particularly in terms of recognizing the major clinical syndromes. These often complicate the course of DILI and as a result, its correction.

Objective: To investigate the frequency of major clinical syndromes in patients with DILI during chemotherapy with normal and excess body weight.

Materials and methods.: A total of 123 patients with DILI without signs of cirrhosis and concomitant liver and biliary tract pathology, aged 35 to 79 years, were examined. The control group consisted of 20 practically healthy individuals.

Results: Evaluating subjective manifestations, it was noted that the asthenovegetative syndrome was present in 45.2% (n=56) of patients who complained of general weakness and rapid fatigue, significantly affecting work capacity. Patients complained of a bitter taste in the oral cavity, changes in dietary behavior in response to changes in appetite, periodic nausea, and a feeling of bloating in the abdomen, which manifested as dyspeptic syndrome in 25.8% (n=32), the latter had a reliable connection with the asthenovegetative syndrome (r=0.65, P<0.05). During the objective examination, an increase in liver size was detected in 51.2% (n=63) of patients, while the feeling of heaviness in the right hypochondrium was felt by 28.5% (n=35) of patients (r=0.62; P<0.05). An increase in blood pressure was diagnosed in 25.2% (n=31) of patients, and arterial hypertension had a reliable dependence on the asthenovegetative syndrome (r=0.64; P<0.05), hepatomegaly (r=0.57; P<0.05), and the feeling of heaviness in the right hypochondrium (r=0.92; P<0.05). Additionally, high normal blood pressure was found in 16.35% (n=20) of patients, and in turn, indicators corresponding to the criteria for stage I hypertension were found in 8.94% (n=11) of those examined.

Conclusions: In patients with DILI during chemotherapy with normal and excess body weight, the presence of asthenovegetative and dyspeptic syndromes, a feeling of heaviness in the right hypochondrium, hepatomegaly, and increased blood pressure were detected, which should be taken into account when choosing treatment tactics.