Endocrine Abstracts

Pituitary microadenomas in children and adolescents are relatively rare, accounting for a small percentage of pediatric endocrine disorders. These benign tumors often present a diagnostic challenge due to their subtle and variable clinical manifestations at this young age. We present clinical and lab data of 5 children with pituitary microadenoma. Case 1: A 12-year-old female with a history of short stature and slow growth velocity was diagnosed with a small pituitary microadenoma. Despite the presence of this lesion, her growth hormone stimulation test was suboptimal, and MRI imaging showed a slightly smaller pituitary gland. Treatment with somatropin led to a significant improvement in height. Case 2: This case involves a 12-year-old female with recurrent headaches, vomiting, dizziness, blurring of vision, early menarche, and recent amenorrhea. MRI confirmed a pituitary microadenoma. She exhibited signs of hormonal imbalances, including elevated ACTH, cortisol, and prolactin levels, suggesting a complex endocrine interaction. Case 3: A 12.4-year-old girl with a history of headaches and fatigue, and a family history of hypothyroidism, was found to have central hypothyroidism and a pituitary microadenoma. Despite levothyroxine treatment, her growth velocity remained low, and her final height was significantly below the mid-parental height. Case 4: This 7-year 10-month-old girl presented with premature thelarche and pubarche. An MRI revealed a microadenoma in the anterior lobe of the pituitary. Her case was complicated by advanced bone age and elevated hormone levels, indicating early pubertal development. She was treated with GnRH analogue injections. Case 5: A 2.8-year-old girl presented with premature thelarche and accelerated growth. Her hormonal profile and advanced bone age suggested early pubertal changes, and MRI confirmed a pituitary microadenoma. She started on triptorelin for management. Clinical and Lab data of the five cases of pituitary microadenoma

Conclusion: These cases collectively demonstrate the diverse presentations of pituitary microadenomas in pediatrics, ranging from growth disturbances to early pubertal changes. The importance of a comprehensive endocrine evaluation and individualized treatment approach in managing these patients is emphasized. The outcomes varied, reflecting the complexity of pituitary disorders in pediatric populations.