Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2024) 99 EP1330 | DOI: 10.1530/endoabs.99.EP1330

ECE2024 Eposter Presentations Late Breaking (127 abstracts)

Primary hyperparathyroidism related to mediastinal ectopic parathyroid adenoma: about 2 cases

Lamiae Zarraa 1 , Siham Rouf 1,2 & Hanane Latrech 1,2


1Endocrinology-Diabetology and Nutrition Department Chu Mohamed VI, Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy Mohammed Premier University Oujda, Morocco, Oujda; 2Morocco, Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy Mohammed Premier University Oujda, Morocco, Oujda


Introduction: Primary hyperparathyroidism is a frequent endocrinopathy characterized by a disorder of phosphocalcic metabolism related to an inappropriate secretion of parathyroid hormone (PTH). Parathyroid adenoma can be located ectopically and represents a particular diagnostic and therapeutic challenge. We report 2 clinical cases of ectopic parathyroid adenoma in mediastinal location.

Observations: Case 1: A 47-year-old patient without any pathological history consulted for paresthesias associated with diffuse joint pain predominantly in the shoulders. The biological assessment revealed hypercalcemia at 146 mg/l, and hypophosphatemia with hypercalciuria at 323 mg/24h. The diagnosis of primary hyperparathyroidism was confirmed by a biointact PTH 1-84 assay at 925 pg/ml on an ectopic parathyroid adenoma located in the upper mediastinum which became intensely and heterogeneously enlarged after injection of PDC measuring 44*20 mm. This nodule insinuated itself into the later-aortic-cava. The management was first medical obtaining normocalcemia followed by surgical treatment with a low cervical approach, the postoperative course was simple and the anatomopathological study was in favor of a benign parathyroid adenoma without signs of malignancy.Cas 2: This is a 59-year-old patient with recurrent renal lithiasis, the etiological finding revealed hypercalcemia at 120 mg/l on a primary hyperparathyroidism with a bio-intact PTH level at 414 pg/ml, and the cervical ultrasound localized a left posteroinferior parathyroid adenoma, the patient was operated and the anatomopathological study concluded to a parathyroid adenoma. Postoperatively, hyperparathormonemia with hypercalcemia was noted, hence the indication of parathyroid scintigraphy which revealed the presence of a mediastinal parathyroid adenoma, the patient refused the surgical treatment and she was put under medical treatment by calcimimetic (Mimpara) with a favorable clinical and biological evolution, especially of the calcemia.

Discussion-Conclusion: Primal hyperparathyroidism is a frequent pathology that requires a topographic diagnosis to rectify surgery when indicated. Ectopic parathyroid adenoma is a rare entity and the advent of new radiological techniques including parathyroid scintigraphy has allowed the topographic diagnosis of this entity.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.