Endocrine Abstracts

Introduction: Familial Non-Medullary Thyroid Carcinoma (FNMTC) is defined as the occurrence of thyroid cancer in two or more first-degree relatives, in the absence of predisposing environmental factors.

Objective of The Study: Describe the epidemiological, clinical features and its evolutionary profile.

Materials and Methods: A retrospective study including 3 families (10 patients) with FNMTC, collected at the endocrinology and diabetology department of Ibn Rochd University Hospital in Casablanca.

Results: Two families had parent-child relationship, and one family consisted of 2 sisters and a nephew. The average age was 38 years, with a clear male predominance and a male-female ratio of 2.3. The circumstances of discovery were mainly multiheteronodular goiter. For one family, three members discovered it during screening at an average young age of 21 years. All patients presented with clinical and biological euthyroidism. All patients underwent total thyroidectomy, with histopathological examination revealing papillary carcinoma in 3 patients, papillary with vesicular or trabeculovesicular differentiation in 5 patients, microcarcinoma in 1 patient, and papillary carcinoma with high columnar cells in 1 patient. The latter had retrospinal lymph node metastases. Multifocality was observed in 20% of patients, and bifocality in 60%. All patients received additional iratherapy. No recurrence was noted in our series.

Conclusions: Although FNMTC have a higher recurrence rate, with an earlier age of onset, no patient in our series had a recurrence. Early diagnosis and screening can improve prognosis and treatment.