Endocrine Abstracts

Iodine deficiency diseases are one of the wide problems seen in the geografically iodine deficiency regions and associated with a large number of people. The goal of our investigation was study of frequency of the thyroid diseases in women with type 1 Diabetes Mellitus (DM1) whose living in Ferghana valley, the iodine deficiency region of Uzbekistan.

Materials and methods: In 120 female patients in age from 18^h to 36 years old with type 1 diabetes blood glucose, HbA1c, TSH, free T4, antiTPO level were measured, thyroid glands were palpated and ultrasound were performed.

Results: Thyroid gland enlargement were found at palpation in all observed woman, with DM1 and in 92.5% without DM1. Estimation of thyroid status showed euthyroidism in 58% DM1 group and 85% without DM, hypothyroidism were registered in 42% woman with DM1 and 15% without DM1. Thyroid glands ultrasound showed in DM1 group 5% woman had nodular, 3.3% mixed goiter and 20% had autoimmune thyroiditis. In group without DM1 nodular goiter were detected in 2.5%, mixed in 3% and autoimmune thyroiditis in 10% woman. In case of nodular and mixed goiter ultrasound results clissified by TIRADS showed 55% TIRADS 1 and 2, 45% TIRADS 3, 4, 5 in DM1 group, whereas in woman without DM TIRADS 1 and 2 seen in 82% and TIRADS 3 and 4 in 18%.

Conclusion: In woman with DM1 lived in iodine defficiency region thyroid diseases were highly presented as a 2 times more nodular goiter and 2 times more autoimmune thyroiditis. Moreover, mallignancy signs incresed by TIRADS on ultrasound imaging. Effective elimination of Iodine defficiency is important in woman with DM1.