Endocrine Abstracts

Objective: assessment of endocrine system profile featuring hormonal and metabolic parameters in persons affected by the ChNPP accident with parathyroid disorders.

Methods and results: Patients treated in the Department of Radiation Endocrinology in 2019-2020 were selected (n=150) by the method of blind sampling in accordance with the study objective. Study sample included the 100 subjects (50% females, 50% males) were affected by the ChNPP accident. The comparison group included 50 patients (55% males, 45% females) not exposed to ionizing radiation. The age of study subjects ranged from 37 to 75 years with 60.2±9.8 years in average. Incidence of parathyroid hyperplasia among persons affected by the ChNPP accident was in twice higher vs the comparison group (41% and 20% respectively) against the background of the same serum level of vitamin 25(OH)D. Average level of parathyroid hormone among the ChNPP accident patients with parathyroid hyperplasia was significantly higher vs. the comparison group (57.2±2.87 and 31.88±4.82 respectively, P<0.05). Mean level of vitamin 25(OH)D in subjects with parathyroid hyperplasia was significantly lower than in cases of no such a disorder (14.36±2.31 and 28.32±6.48 respectively, P<0.05). Relationships between the hormones and metabolic profile using the correlation- regression analysis showed a significant negative effect of secondary hyperparathyroidism on comorbid conditions, namely the endocrine component of arterial hypertension, dyslipidemia, osteopenia and metabolic syndrome. Using multivariate analysis, a reliable relationship was established between the vitamin 25(OH)D deficiency and astheno-neurotic, anxiety-depressive syndromes (F=83.811; P=0.0001), autoimmune thyroiditis, hypothyroidism (F=8.1802; P=0.0001), type 2 diabetes mellitus and metabolic syndrome (F=16.428; P=0.0001). Also the multivariate analysis provided a reliable confirmation of the negative impact of hyperparathyroidism on arterial hypertension and arrhythmia (F=8.8469; P=0.0007), osteopenia (F=16.208; P=0.0001).

Conclusions: Secondary hyperparathyroidism has a negative effect on the course of concomitant endocrine disorders and comorbid conditions.