Endocrine Abstracts

Introduction: Hyperglycemia is often elevated in patients with acute myocardial infarction (AMI) and is a prognostic indicator. According to a number of researchers, the risk differs between women and men. The purpose of our study was to study the effect of hyperglycemia on clinical and biochemical parameters in men and women with AMI.

Materials and methods: The study was conducted on 92 patients admitted to the intensive care unit of the cardiology center in Bukhara. Of these, 65% are men and 35% are women, aged from 42 to 84 years. Among them, 16 patients had a history of type 2 diabetes. All subjects were measured for BMI, SBP, DBP, general blood count, urine test, glycemia, HbA1c, ALT, AST, blood urea and creatinine levels, and coagulation parameters according to a coagulogram.

Results: The results showed that AMI was more common in men (1.78 times) compared to women, while the increase in glycemia was observed in women by 1.87 times higher compared to the group of men. BMI, SBP, DBP, and blood biochemical parameters did not differ significantly in the group of men and women. However, the dependence on glycemia assessed by correlation showed an average correlation between BMI in the group of men with normoglycemia, while in women this relationship was positive in both the group with normoglycemia and hyperglycemia. A positive correlation was found between the parameters of SBP, leukocytes, blood platelets, with proteinuria, prothrombin index, D-dimer. Interestingly, a positive correlation with glycemia was detected with both normo- and hyperglycemia; there was a weak correlation with BDNF levels.

Conclusions: AMI is more common in men than in women. At the same time, clinical and laboratory parameters did not differ significantly. A correlation was found with BMI, SBP, blood leukocyte level, blood D-dimer, and a weak correlation was noted with blood BDNF level, which suggests their consideration as prognostic criteria for the prognosis of AMI.