Endocrine Abstracts

Objective: To assess the features of the manifestation of sarcopenia (SP) in patients with diabetes mellitus (DM), taking into account the body composition.

Materials and study methods: The study included 87 patients with DM (29 men - 33% and 58 women - 67%). The average age of patients was 41.59±11.84 years and duration of diabetes was 12.51±6.39 years. The study included anthropometric measurements: mass body index (BMI), waist circumference (WC), shin circumference (SC). Muscle strength (MS) was determined using hand dynamometry, and muscle function (MF) was assessed using a 4-meter walking speed test. Taking into account WC, patients were divided into 2 groups: the first group (n=45) WC less than 80 cm for women and less than 94 cm for men and the second group (n=42) with WC exceeding these target parameters taking into account gender. Statistical processing of the data array was performed using the statistical program «Statistica 10.0» (StatSoft, GS35F-5899H). The level P<0.05 is considered as a criterion for the statistical confidence of the results.

Study results and discussion: When assessing SP parameters in patients with DM, the groups differed significantly in muscle mass (MM) assessed by SC (SC first group 35.00 [34.00; 36.00]cm, second group 38.00 [37.00; 39.00] cm) and MF (first group 4.00 [4.00; 4.00] points, second group 3.00 [3.00; 4.00] points ) P<0.05. There were no significant differences in MS between the groups (first group 27.27 [20.50; 37.00] kg, second group 21.00 [18.00; 31.50] kg) P>0.05. There was a decrease in MM in 14% of patients in the first group and in 8% of patients in the second group. A decrease in MF prevailed in patients in the second group (62%), while in the first group a decrease in MF was not noted. The decrease in MS prevailed in patients in the second group (first group – 29%, second group – 46% of patients) P<0.05.

Conclusions: Decreased MS (46% of patients) in patients with DM, which determines the probability of SP, and decreased MF (62% of patients) were noted in patients with WC and BMI exceeding the target values, and decreased MM prevailed in patients with WC and BMI corresponding to the target normal values.