ECE2024 Eposter Presentations Adrenal and Cardiovascular Endocrinology (155 abstracts)
Precocious puberty: a case report
Omaima Hammami 1 , Ines Mezghani 1 , Rim Marrakchi 1 , Souhir Maalej 2 , Faten Hajkacem 2 , Mariem Boudaya 1 , Kamel Jammoussi 1 , Nabila Rekik 2 , Mohamed Abid 2 & Mouna Turki 1
1Hedi Chaker University Hospital, Biochemistry Departement, sfax, Tunisia; 2Hedi Chaker University Hospital, Endocrinolgy Departement, sfax, Tunisia
Introduction: Precocious puberty is characterized by the onset of signs of puberty before the usual age and can be caused by various etiologies. Congenital adrenal hyperplasia represents a rare cause of precocious puberty. Our aim was to report a case of a child with precocious puberty.
Observation: A 4-year-old and 11 months patient, from a consanguineous marriage, hospitalized in the endocrinology department for precocious puberty. The clinical examination found a child in good general condition, a bone age of 13 years, a stature advancement of +1 standard deviations (SD) and the presence of a dysmorphic syndrome including a rounded forehead, an enlarged nose, almond-shaped eyes, micrognathism, retrognatism, slight hypotelorism, and bilateral ulna valgus. The hormonal assessment shows a high testosterone level of 3.25 nmol/l. The 17-OH progesterone was highly elevated (20 ng/ml), cortisol at 8 a.m: 51.3 ng/mL, FSH: 0.6 mIU/ml, LH is low, less than 0.1 mIU /ml, androstenedione was elevated to 0.11 ng/mL and SDHEA was increased to 7.58 µg/mL. The diagnosis of congenital adrenal hyperplasia linked to a 21 OH adrenal enzyme block was made, the genetic study is in progress and the patient received hydrocortisone at a reducing dose of 10 mg/m2/day, divided into 2 taken.
Conclusion: congenital adrenal hyperplasia due to enzymatic block represents a complex clinical cause that requires a careful diagnostic and therapeutic approach. This disorder, although rare, can lead to early manifestations of puberty, posing significant challenges for healthcare professionals.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more