Endocrine Abstracts

Introduction: Precocious puberty results from the premature activation of the gonadal axis. It mimics physiological pubertal development, although at an inappropriate chronological age (before 8 years in girls and 9 years in boys). It is a serious challenge with repercussions on physical and psychosocial development. We aimed to evaluate the different etiology of Precocious puberty and the effectiveness of the Gonadotropin-releasing hormone (GnRH ) agonists.

Patients and methods: This is a retrospective, descriptive study including a total of thirty-four children with precocious puberty follow-up in the Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital, Oujda, Morocco. A clinical examination, statural evaluatiol and hormonal settings were performed in all cases. Statistical analysis was performed using SPSS version 21.

Results: The average age of our study group in the first consultation was 5,77±2,28 years. Thirty one girls and 3 boys. Sixty-five percent of the patients were consulted in the first year of evoluation. The most common consultation reason was breast development (35%), followed by pubic hair develpement (27%). Statural advancement was found in 47%, with a bone age differance more than 2 years in 35%. LHRH testing was carried out in 83% of patients. Central precocious puberty was predominant with 24%. Fourty-four percent of our patients were treated with agonists GnRH. Post-treatment evaluation revealed that 73% of des patients presented stability or regression of signs.

Discussion and conclusion: Early diagnosis of precocius puberty can prevent short stature in adulthood. LHRH testing is the key test to. Treatment by GnRH agonists has demonstrated efficacy in central precocious puberty.

References: 1. Latronico, A. C., Brito, V. N., & Carel, J.-C. (2016). Causes, diagnosis, and treatment of central precocious puberty. The Lancet Diabetes & Endocrinology, 4(3), 265–274. 2. Carel, J.-C. (2005). Le traitement des pubertés précoces par agonistes de la GnRH. Annales d’Urologie, 39, S85–S88. 3. Kim HK, Kee SJ, Seo JY, Yang EM, Chae HJ, Kim CJ. Gonadotropin-releasing hormone stimulation test for precocious puberty. Korean J Lab Med. 2011 Oct;31(4):244-9.

Key words: Precocious puberty – agonistes GnRH