Endocrine Abstracts

Introduction: Rheumatological manifestations are frequent in Cushing’s disease with impact on quality of life.

Objective: The aim of our study is to describe rheumatological manifestations in Cushing’s disease

Material and methods: Retrospective study of 51 patients diagnosed for Cushing’s disease followed in the Endocrinology of CHU IBN Rochd from Casablanca from 2012 to 2023. Osteo-articular complications were detected either at diagnosis or during monitoring. The statistical analysis was done by the SPSS version 25 software.

Results: We included 51 patients including 45 women and 6 men, the average age of patients was 36.20 years (17-69). The average seniority of the disease was 2.5 years. The average Clu was 657 UG/24 hours (116.8 - 2196). To pituitary MRI: macroadenoma in 27 patients, microadenoma in 21 patients and normal in 5 patients. On the clinical level: gonalgia 49% (n=25), lumbar dorso rachialies 58.82% (n=30), diffuse arthralgia 11.76% (n=6), shoulder arthralgia 7.84% (n=4), arthralgia of the elbow 7.84% (n=4). Biologically: moderate hypocalcemia in 4 patients, hypophosphoremia in 2 patients, hypovitaminose D in 58.82% (n=30). To osteodensitometry: osteopenia of the femur 17.65% (n=9), wrist osteopenia 27.45% (n=14), osteopenia of spine 11.76% (n=6), osteoporosis of the 31.37% (n=16), osteoporosis of the femur 7.84% (n=4) and normal 27.45% (n=14).

Conclusion: Rheumatological complications are frequent in Cushing’s disease dominated by lumbar dorso rachialgia, hypovitaminose D and spine osteoporosis.