Endocrine Abstracts

Background: Non functional adrenal incidentalomas (NFAI) constitute the majority of adrenal tumors. This entity is a result of advances in imaging techniques and their prevalent use in clinical practice. Among the associated metabolic effects of NFAI, dyslipidemia emerges as a key factor, stimulating growing interest in understanding the link between these two entities.

Methods: This case control study included 40 NFAI patients (16 men, 24 women, mean age 52.9±11.2 years) and 40 individuals (17 men, 23 women, mean age 56.8±8 years) in the control group matched for age, sex, and weight. NFAI diagnosis was established according to current guidelines. Patients with mild autonomous cortisol secretion, chronic kidney disease, liver failure or under hypolipidemic drugs, combined contraceptive pills, alcohol or depression, were excluded of this study. All participants underwent adrenal imaging, biochemical evaluation including triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), cholesterol total (CT), Low-density lipoprotein cholesterol (LDL-C). Dyslipidemia was defined according to the National Cholesterol Education Program (NCEP) ATP III.

Results: The prevalence of dyslipidemia was 52,5% in NFAI patients compared to 57.5% in the control group. HypoHDLemia represented the most common type of dyslipidemia in both groups, 35%and 33% respectively. Hypercholesterolemia and hypertriglyceredemia were diagnosed respectively in 20% and 18% of NFAI patients vs 25% and 18% in control group.

Conclusion: Our study didn’t show a higher prevalence of dyslipedemia in NFAI patients. However, management of dyslipidemia in NFAI should be considered for primary and secondary prevention of cardiovascular risk.