ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)
A simple blood screening tests for predicting non-alcoholic fatty liver disease in obese patients
Meriam Dalhoum 1 , Olfa Berriche 1 , Rim Ben Othmen 1 , Emna Talbi 2 , Raja Tlili 3 , Sahar Hamza 3 , Amel Gammoudi 1 , Awatef Kacem 1 , Lamia Kallel 3 & Henda Jamoussi 1
1National Institute of Nutrition in Tunis, Human Obesity Research Unit, Tunis, Tunisia; 2National Institute of Nutrition in Tunis, Biochemistry Laboratory, Tunis, Tunisia; 3Mahmoud El Matri Hospital, Ariana, Tunis, Gastroenterology Department, Tunis, Tunisia
Introduction : Obesity is becoming increasingly common in the world’s population. Its pandemic nature has made it the leading cause of chronic liver disease especially non-alcoholic fatty liver disease (NAFLD).
Objective: To develop a simple blood screening tests to predict the risk of NAFLD in the obese patient.
Methods and Materials: This is a cross-sectional study including 208 patients who consulted at the Human Obesity Research Unit of the National Institute of Nutrition in Tunis. Patients were interviewed, anthropometric measurements (weight, height, body mass index (BMI) and waist circumference) were taken, biological hepatic assessment (aspartate transaminase (AST), alanine transaminase (ALT), Gamma-glutamyl Transferase (GGT) and Alkaline phosphatases (ALPs)) and abdominal ultrasound were conducted to look for hepatic steatosis. We subdivided our patients into two groups: G1 (patients with hepatic steatosis) and G2 (patients without hepatic steatosis).
Results: The mean age of our patients was 49±12 years with a female predominance (98.9%). The mean BMI was 40,43±6,38 kg/m2. The mean waist circumference was 117,60 ±14,58 cm. The frequency of hepatic steatosis was 76 %. Mean AST, ALT and GGT levels (IU/l) were significantly higher in the presence of steatosis, respectively G1: 25.30±14; 21±16 and 24±18 vs G2: 20.72±6; 17.23±13 and 18±15 (P=0.036; P<0.001 and P=0.006 respectively). Similarly, PAL levels (IU/l) were higher in G1, but with no statically significant difference (G1: 83.67±21 vs G2: 79.26±26; P=0.246). The AST/ALT ratio was significantly lower in G1 (G1: 1.07±0.31 vs G2: 1.27±0.35; P<0.001). In multivariate analysis, only ALT (OR= 1.109; P=0.001) predicted NAFLD.
Conclusion: Hepatic steatosis is common in obese subjects and the hepatic screening tests represents a simple and reliable way for early early detection.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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