Endocrine Abstracts

Introduction: Diabetes mellitus is the most common disease of the 21st century. The main challenge for modern doctors is to prevent its development.

Purpose: Study the state of carbohydrate metabolism in individuals with different obesity phenotypes.

Materials and methods: We examined 96 individuals (18-64 y.) according to each obesity phenotype during 2019 - 2021 on the basis of the Vinnitsa Regional Clinical High-Specialized Endocrinological Center. An anamnesis was collected according to the FINDRISK Diabetes risk scale. Biochemical analysis was performed laboratory.

Results: Patients in the first clinical group have normal body weight, some have overweight (BMI - 24.7±4.3 kg/m²), but the waist volume (102.45±9.63 cm in men, 88.64±4.27 cm in women) is higher than the normative values, which is tracked in all obesity phenotypes, which may indicate insulinresistance. Violations of carbohydrate and lipid exchanges according to screening surveys in this group were not found. With normal body weight (BMI-23.7±2.44 kg/m²), metabolic disorders are already observed in the second clinical group. According to carbohydrate metabolism data, all patients were diagnosed with prediabetes combining fasting hyperglycemia and impaired glucose tolerance (fasting glucose - 5.93±0.36 mmol/l, 2 hours after glucose - 8.45±0.27 mmol/l, HbA1c - 6.23±0.18%), and existing dyslipidemia (CL - 5.88± 0.26 mmol/l). It is worth noting that not always as we expect in obesity (BMI - 34.57±3.31 kg/m²) there will be changes in the lipid and carbohydrate profile, demonstrating the results of the examination of the 3rd clinical group (fasting glucose - 5.23±0.17 mmol/l, glucose 2 hours after glucose - 7.4±0.32 mmol/l, HbA1c - 5.32±0.21%; CL - 4.98±0.46 mmol/l, TG - 1.32±0.14 mmol/l, LDL - 2.75±0.22 mmol/l). In patients of the 4th clinical group, metabolic disorders were detected (fasting glucose - 5.78±0.13 mmol/l, glucose 2 hours after glucose - 8.83±1.67 mmol/l, HbA1c - 5.97±0.32%; CL - 6.73± 0.21 mmol/l, TG - 2.46± 0.57 mmol/l, LDL - 4.13± 1.07 mmol/l, SAP - 145.58±19.34 mm Hg, DAP - 94.8 ±5.61 mm Hg) with obesity (BMI - 35.8 ±4.42) Given a long course without proper treatment, this can provoke diabetes mellitus.

Summary and conclusions: The results of the study will give rise to timely preventive measures aimed at combating diabetes mellitus.