Acromegaly revealed by unstable diabetes

Karimi Meryem; Ali Halouache; Isswani Jad; Anas Guerboub Ahmed

doi:10.1530/endoabs.99.EP1113

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Endocrine Abstracts (2024) 99 EP1113 | DOI: 10.1530/endoabs.99.EP1113

ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)

Acromegaly revealed by unstable diabetes

Karimi Meryem ¹ , Ali Halouache ² , Isswani Jad ² & Guerboub Ahmed Anas ²

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¹Ibn Sina Rabat, Endocrinology Rabat, Morocco; ²Hôpital Militaire D’Instruction Mohammed V, Endocrinology Rabat, Morocco

Introduction: Acromegaly is a rare condition characterized by the hypersecretion of growth hormone (GH), resulting in morphological anomalies, metabolic disturbances, including overt diabetes, and endocrine abnormalities.

Case Report: We present the case of a 54-year-old patient with a history of cervical lumbar sciatica under treatment. The disease history dates back 3 years with the onset of polyuria-polydipsia syndrome and fatigue. On clinical examination, the patient exhibits acrofacial dysmorphic features. The laboratory findings revealed an HbA1c of 8%, IGF1 level twice the normal range. Hypothalamo-hypophysial MRI reveals a 12 mm pituitary macroadenoma without invasion of the cavernous sinuses. The patient was prescribed oral antidiabetic drugs and subsequently referred to a neurosurgeon for surgical intervention.

Discussion and Conclusion: Acromegaly is an insidious and slowly progressive pathology, often leading to a late diagnosis. This prolonged diagnostic delay is responsible for the onset of complications, including diabetes.