ECE2024 Eposter Presentations Reproductive and Developmental Endocrinology (78 abstracts)
The relevance of endocrine disruptors, obesity, and cytokines for polycystic ovary syndrome
Michaela Duskova 1,2 , Jana Vítků 3 , Lucie Kolatorova 4 , Jana Vrbikova 4 , Michala Vosátková 3 , Josef Včelák 5 & Markéta Šimková 5
1Institute of Endocrinology, Department of Steroids and Proteofactors, Praha 1, Czech Republic; 2General Teaching Hospital Prague, 4th department of internal medicine, Praha, Czech Republic; 3Institute of Endocrinology, Department of Clinical Biochemistry, Praha 1, Czech Republic; 4Institute of Endocrinology, Department of Clinical Endocrinology, Praha 1, Czech Republic; 5Institute of Endocrinology, Department of Molecular Endocrinology, Praha 1, Czech Republic
As genetic and environmental components contribute to the PCOS expression, we compared levels of endocrine disruptors, steroid hormones, cytokines, and metabolic parameters in twenty healthy, nine normal-weight PCOS women, and ten obese PCOS women. Steroid hormones, bisphenols (BPA, BPS, BPF, BPAF) and parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-parabens) were measured by liquid chromatography-tandem mass spectrometry. Differences between the groups were assessed using the Mann-Whitney U test. Spearman correlation coefficients were calculated for the individual parameters relationship. Significantly higher levels of BPA, Anti-Müllerain hormone, lutropine, lutropine/folitropine ratio, testosterone, androstenedione, 7β-OH-epiandrosterone, and cytokines (IL-6, VEGF, PDGF-bb), were found in normal-weight PCOS women compared to controls. In PCOS women concerning the weight, there were no differences in hormonal, but in metabolic levels. Obese PCOS women had significantly higher insulin resistance, fatty-liver index, triglycerides, cytokines (IL-2, IL-13, IFN-γ). In healthy, but not in PCOS, women, there was a positive correlation of BPA with testosterone, SHBG with lutropine, and folitropine, while testosterone negatively correlated with SHBG. In obese women with PCOS, insulin resistance negatively correlated with SHBG and estradiol. No differences were observed in the paraben exposure. Levels of BPA were higher in PCOS women, indicating its role in the etiology. Obesity significantly worsens the symptoms.
Acknowledgements: This study was supported by the Ministry of Health of the Czech Republic (MZ ČR – RVO; Institute of Endocrinology - EÚ, 00023761).
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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