Endocrine Abstracts

Introduction: In the context of Type 2 Diabetes (T2D), understanding the interplay between testosterone levels and anthropometric data holds crucial implications. This study aims to explore the intricate relationship between testosterone, obesity, and anthropometric measurements, offering insights that contribute to a deeper understanding of the intricate physiological dynamics within this diabetic population.

Methods: This Cross-Sectional Study included 250 men with T2D consulting at the National Institute of Nutrition in Tunisia. Free Testosterone (FT) and Bioavailable Testosterone (BT) using the Vermeulen formula¹. For all patients we measured weight, height and waist circumference (WC). Body mass index (BMI) was calculated. Obesity was defined by a BMI > 30 kg/m²;, and android fat distribution was identified by a waist circumference (WC) ≥ 94 cm.

Results: The median age of our participants was 58 years, with an interquartile range (IQR) of [52.7–62]. The average weight of the patients was 83.3±12.4 kg [59 - 125 kg]. The mean Body Mass Index (BMI) was 27.9±4 kg/m²;,[19.8 -40]. Approximately 29.2% of patients were classified as obese, (n=73 patients). In terms of anthropometric measurements, the mean WC was 97.5±9.2 cm, [77 - 138 cm]. Android distribution of body fat was observed in 67.2% of participants, accounting for 168 individuals. A significant inverse correlation was found between BMI and the levels of Total Testosterone (TT) (r: -0.311; P<10^-3), FT (r: -0.150; P=0.021), and BT (r: -0.143; P=0.027). The same relationship exists between WC and levels of TT (r: -0.275; P<10^-3), FT (r: -0.146; P=0.024), and BT (r: -0.136; P=0.038).

Conclusion: These findings suggest a significant negative association between BMI, waist circumference, and testosterone levels, emphasizing the potential role of testosterone in the regulation of body composition within this specific population.

References: 1. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84(10):3666-3672. doi:10.1210/jcem.84.10.6079