Endocrine Abstracts

Background: Hypophosphatemic rickets are disabling conditions that negatively impact physical functioning, activities of daily living, mental health, social life, and leisure activities. The most common cause of Hypophosphatemic rickets is genetic factors, such as X-linked hypophosphatemia. The evaluation of the scientific application of familial hypophosphatemic rickets aids in understanding the research landscape, identifying opportunities for improvement, and promoting significant advancements in the understanding and treatment of this medical condition.

Methods: An observational, descriptive, and cross-sectional study was conducted through a bibliometric analysis of the scientific output of the Familial Hypophosphatemic Rickets published in journals indexed in Scopus during 2020-2022. To retrieve the publications, Scopus was accessed on April 4, 2023, and an advanced search was performed using a filter by title, abstract and key words, source (journals), publication year, and type of article (article and review). The search terms used were extracted from the PubMed Medical Subject Headings (MeSH) related to the disease included in the MeSH catalog. Additionally, an analysis of co-occurrence between countries and keywords was carried out with VOSviewer software.

Results: This study identified 1,269 articles on hypophosphatemic rickets (938 articles and 331 reviews). In total, 39,548 citations were received, with an H index of 95. The majority of the articles (76.9%) were published in high-impact journals (Q1 and Q2 journals). Scientific production has shown a growing trend in recent years. The countries with the highest scientific production are the U.S, Japan, and the United Kingdom, considering that middle- and low-income countries contribute less to international scientific production.

Conclusions: Scientific production has shown sustained growth in recent years. The U.S solidifies itself as the country leading scientific production on hypophosphatemic rickets.

Keywords: bibliometrics, familial hypophosphatemic rickets, rickets, FGF23 protein, PHEX protein, X-linked hypophosphatemic rickets, burosumab.