Endocrine Abstracts

Pituitary tumors are infrequently seen in an endocrine practice. We collected retrospective data from our clinical records of our patients with pituitary tumors from January 2018 to December 2023. There were a total 31 patients; males 9 (29.03%) and females 22 (70.97%). Mean age was 38.54±12.37 years and average BMI was 26.10±3.91. Headache and visual problem was the most common symptom in 13 (41.9%) patients each followed by menstrual irregularity in 8 (25.80%) patients. Hypertension was seen in 12 (38.70%) patients and diabetes seen in 9 (29.03%) patients. Nonfunctioning pituitary adenoma (NFPA) was seen in 8 (25.80%) patients. Most NFPA were macroadenoma 6 (75%). Functioning pituitary adenoma(FPA) was seen in 23 (74.20%) patients. Somatotroph adenomas were 8 (34.78%), prolactinomas were 7 (30.43%), ACTH secreting tumors were 7 (30.43%), thyrotropinoma was 1(4.35%). Most somatroph adenomas were macroadenomas 6(75%). Most prolactinomas were macroadenomas 4 (57.14%). Most ACTH secreting tumours were microadenomas 6 (85.71%). Optic chiasmal compression was seen among 12 (38.71%) patients and all had macroadenomas and 7(58.33%) had functioning tumors. Cavernous sinus invasion was seen in 12 (38.71%) patients and all had macroadenomas. Treatment of NFPA was surgical in 5 patients (62.5%), conservative in 2 (25%) patients and 1 (12.5%) patient underwent combined procedure (surgery and conventional radiotherapy). Mean follow up period of NFPA who underwent surgery was 29.33 months, and mean decrease in tumor size was 27.26 mm (in greatest dimension). All of the tumor removal was possible in 2(33.33%) patients. Treatment of FPA was surgical in 12 (52.17%)patients. Mean follow-up years of FPAs who underwent surgery was 54.83 months and mean decrease in tumor size was 18.02 mm (in greatest dimension). All of the tumor removal was possible in 4(30.77%) patients. Among 8 patients with acromegaly, 6 patients had surgery, 1 patient had cyberknife surgery and 1 patient lost to follow up. Among 7 patients with prolactinoma, 2 patients had surgery and all patients were treated with cabergoline. One patient with prolactinoma underwent a combined procedure (surgery and radiotherapy). Among 7 patients with ACTH secreting tumors, 4 patients had surgery, 2 had medical treatment with ketoconazole and 1 lost to follow up.