ECE2024 Eposter Presentations Reproductive and Developmental Endocrinology (78 abstracts)
Lipid profile in women with PCOS and their phenotypes
Lena Radic 1 , Sanja Ognjanovic 1 , Bojana Popovic 1 , Dusan Ilic 1 , Jelica Bjekic Macut 2 , Valentina Elezovic Kovacevic 1 , Milica Opalic Palibrk 1 , Katarina Krstic 1 , Dragan Hrncic 3 , Danijela Vojnovic Milutinovic 4 & Djuro Macut 1
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Department for Endocrine Tumors and Hereditary Cancer Syndromes, Belgrade, Serbia; 2Clinical Hospital Centre Bezanijska Kosa, Belgrade, Serbia; 3Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 4IBISS, University of Belgrade, Belgrade, Serbia, Belgrade, Serbia
Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance, dyslipidaemia and hyperandrogenism. The aim of the research was to analyse lipid profile in women with PCOS and their phenotypes.
Subjects and methods: We evaluated 159 women with PCOS diagnosed using ESHRE/ASRM criteria (PCOS: age: 25.85±5.14 years, BMI 23.75±5.54 kg/m2) and 51 BMI-matched healthy women (Controls: age: 28.02±5.35 years, BMI 23.17±4.98 kg/m2). PCOS group was divided into four phenotypes: A (anovulation (ANOV), hyperandrogenism (HA), polycystic ovary morphology (PCOM)), B (ANOV, HA), C (HA, PCOM), D (ANOV, PCOM). We measured levels of lipid indices, total testosterone, SHBG and androstenedione, while values of free androgen index (FAI) were calculated.
Results: Our analysis showed that there were significantly higher triglyceride levels in PCOS group in comparison to controls (PCOS:Controls: 0.95±0.49 vs 0.812±0.49, P=0.014), while the levels of total cholesterol, LDL and HDL cholesterol were similar in both groups (P>0.05). There were significantly higher levels of total testosterone, FAI and androstenedione (P<0.001), as well as significantly lower levels of SHBG (P<0.001) in women with PCOS. Comparison of lipid profile between PCOS phenotypes showed that phenotypes B and C differ in triglyceride levels, which were significantly higher in phenotype B (PCOS B:PCOS C: 1.10±0.51 vs 0.84±0.35, P=0.049), while the concentration of other lipid parameters between groups was similar (P>0.05 in all comparisons). Triglyceride levels showed positive correlation with FAI in PCOS phenotype B (r=0.551, P=0.018).
Conclusion: In our study we showed that there is a difference in triglyceride levels between metabolic and reproductive phenotypes of PCOS. Positive correlation between triglycerides and FAI in phenotype B represents a direct influence of the PCOS phenotype on metabolic consequences and relevant cardiometabolic outcomes during life.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more