Endocrine Abstracts

Introduction: Cardiovascular diseases are frequent in patients with hypopituitarism receiving conventional hormone replacement therapy. They represent the main cause of premature death in this population. Emerging evidence smggests that beyond traditional risk factors, evaluating coronary calcium score (CCS) and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) provides valuable insights into cardiovascular health in this population. The aims of the pre...

Aim: Role of Endocrine Specialist Nurse (ESN) in performing cannulated prolactin and subsequent impact on outpatient clinic activities.Introduction: Hyperprolactinemia is a common condition in endocrine clinical practice. It may occur in any sex, at any age and its prevalence and incidence depend on study population. The most common physiological causes of elevated prolactin are stress, lactation, pregnancy and exercise. Non-physiological causes include ...

Growth hormone deficiency (GHD) diagnosis poses a significant challenge since no test definitively diagnoses GHD. The current diagnostic approach for GHD relies on a determination of auxologic parameters followed by determining Growth Hormone (GH) levels and Insulin-like Growth Factor-I (IGF-I) in serum. However, clinical assessment and interpretation of GH and IGF-1 levels lack sensitivity. Further provocative studies of GH secretion do not have a precise cutoff level that di...

Non-functioning pituitary neuroendocrine tumors (NF-PitNETs) are still orphan of medical therapy. The drmgs approved for the other types of PitNETs, e.g. somatostatin analogues (SSA) with high affinity for somatostatin receptors (SSTs) type 2 (SST2) and 5 (SST5) are poorly efficacious in NF-PitNETs. Among SSTs, NF-PitNETs express high levels of SST3, a receptor that can mediate antiproliferative and apoptotic signaling. ITF2984 is a pan-SST ligand with high affinity for SST3, ...

Context: Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion, mostly induced by pituitary adenomas. The care of pregnant women with acromegaly is challenging, in part due to existing clinical data being limited and not entirely consistent with regard to potential risks for mother and child.Objective: To retrospectively examine data on pregnancy and maternal as well as neonatal outcomes in patients with acromegaly.<p class="...

Context: Although diabetes mellitus is a major complication in patients with acromegaly, prevalence and determinants of microvascular and macrovascular complications of diabetes remains unexplored in this population.Aim: To investigate prevalence and determinants of microvascular and macrovascular complications in acromegaly patients with diabetes and to compare them with a group of diabetic patients without acromegaly.Methods: Pro...

Introduction: Pituitary apoplexy is a rare clinical syndrome that often involves headache, visual deficits, and endocrine dysfunction resulting from infarction or hemorrhage of a pituitary tumor. Due in part to the rare nature of this condition, there are few large studies on pituitary apoplexy described in the literature. Here, we present a large single center retrospective cohort study of patients with pituitary apoplexy managed surgically or conservatively.<p class="abs...