Endocrine Abstracts

Introduction: Pheochromocytoma, a rare catecholamine-secreting adrenal tumor, can cause hypertension and life-threatening complications. Hereditary cases have an increased risk of developing bilateral disease. Standard treatment involves radical adrenalectomy, leading to adrenal insufficiency in bilateral cases. Partial adrenalectomy aims to preserve adrenal function but has higher recurrence rates. This study compares outcomes of partial vs radical adrenalectomy in hereditary...

Background: Somatic and bi-allelic DICER1 mutations have been reported in subsets of sporadic thyroid tumors, affirming a clear involvement of this gene in the development of thyroid tumors. As a recent study has highlighted associations between DICER1 mutations and macrofollicular patterns, abortive changes, and papillary structures, we aimed to investigate these observations in a bi-institutional cohort.Methods: A total of 61 thyroid lesions (...

Background: Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine disease in which 60% of patients show endogenous glucocorticoid (GC) secretion that potentially contributes to a lack of immune cell infiltration and limited efficacy of immunotherapeutic approaches. In another study, we already demonstrated potent antitumor efficacy or ROR1 CAR-T cells in preclinical models of ACC. Nevertheless, solid tumors often show cell intrinsic resistance mechanisms to CAR-T c...

Introduction: The steroidogenesis inhibitor osilodrostat (OSI), indicated for the medical treatment of endogenous Cushing’s syndrome, exhibits significant interindividual variability regarding the response to treatment (Pivonello et al., 2020), a fortiori in the context of adrenocortical carcinoma (Tabarin et al., 2022). Plasma exposure may contribute to this variability. Our objective was to investigate the effect of concomita...

Introduction: The intricate interplay between fibroblasts and cancer cells significantly contributes to cancer invasion, extracellular matrix (ECM) modulation, and the development of drmg resistance. This study delves into understanding the specific influence of fibroblasts on Gastro-Intestinal neuroendocrine tumor (GI-NET) cell lines.Materials and Methods: Utilizing GOT1 and COLO320 cell lines, we incorporated Normal Human Dermal Fibroblasts (NF) in our...

Insulinomas are rare insulin-producing pancreatic neuroendocrine tumours. Most insulinomas are non-metastatic and can be cured by surgery, but in 10% of the patients insulinomas metastasize, which is associated with a significantly impaired overall survival. As the metastatic potential of an insulinoma cannot be reliably predicted with the current biomarkers, we aimed to evaluate the expression of somatostatin receptors (SSTRs) and glucagon-like peptide-1 receptors (GLP-1Rs) i...