ECE2024 Rapid Communications Rapid Communications 6: Thyroid | Part I (5 abstracts)
Maternal thyroglobulin and thyroid function during pregnancy and offspring neurodevelopment
Tessa Mulder 1 , Mònica Guxens 2 , Sarah Bath 3 , Mariana Dineva 3 , Amaia Irizar Loibide 4 , Nerea Lertxundi 4 , Maria Luisa Rebagliato Ruso 5 , Henning Tiemeier 1,6 , Robin Peeters 1 & Tim Korevaar 1
1Erasmus University Medical Center, Rotterdam, Netherlands; 2ISGlobal, Barcelona, Spain; 3University Of Surrey, United Kingdom; 4Biodonostia Health Research Institute, San Sebastian, Spain; 5Jaume I University, Castelló de la Plana, Spain; 6Harvard T.H. Chan School of Public Health, Boston, United States
Background: Low maternal urinary iodine concentration (UIC) during pregnancy has been associated with lower child IQ and differences in brain morphology. However, UIC is highly variable as it is a reflection of 24-h urinary intake rather than long-term iodine status. Thyroglobulin (Tg) might be a more sensitive biomarker of the long-term maternal iodine status.
Aim: To study whether maternal Tg is associated with maternal and newborn thyroid hormone concentrations, offspring IQ and brain morphology and if these associations differ by UIC.
Methods: We selected participants from two population-based prospective cohorts: Generation R (the Netherlands) and INfancia y Medio Ambiente (INMA; Spain) with available measurements of maternal Tg and thyroid function at 13 weeks of gestation (n=4,438 women) or at birth (n=2,082 mother-child pairs), early childhood IQ (n=2,984; age 4.5 and 6 years) or late childhood IQ (n=2,569; age 9 and 13 years), and offspring brain morphology at 10 years (n=1,197). The associations of Tg with TSH and FT4 concentrations, IQ and brain MRI outcomes were studied with multivariable linear regression.
Results: Higher maternal Tg was associated with lower TSH (P<0.001), higher FT4 (P<0.001) and lower IQ in early childhood (-0.06 point per 1 ng/ml Tg, P=0.02). Tg was not associated with cord blood TSH or FT4, late childhood IQ or brain morphology. We found no clear evidence of effect modification by UIC.
Conclusions: Tg is associated with thyroid function during pregnancy and some markers of offspring neurodevelopment. However, further research should determine the added value of Tg in addition to UIC for defining iodine status.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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