Endocrine Abstracts

Introduction: Thyroid disorders are generally diagnosed based on thyroid stimulating hormone (TSH) outside the reference interval (RI), and subsequent free thyroxine (FT4) concentrations. Most laboratories do not provide age-specific RIs for TSH and FT4 beyond childhood, although it is known that TSH concentrations vary with age which may be important to take into account. Therefore, we aimed to establish age-specific RIs for TSH and FT4 throughout life using an indirect metho...

Objective: Thyroid peroxidase antibody (TPOAb) positivity is the most important risk factor for overt/subclinical hypothyroidism and partly guides levothyroxine treatment indications during pregnancy. TPOAb positivity is usually defined by manufacturer cutoffs which are typically derived in non-pregnant populations with concentrations ≥95th percentile. Besides the general lack of assay uniformity, current TPOAb positivity cutoffs are likely to underestimate gestational t...

Background: Low maternal urinary iodine concentration (UIC) during pregnancy has been associated with lower child IQ and differences in brain morphology. However, UIC is highly variable as it is a reflection of 24-h urinary intake rather than long-term iodine status. Thyroglobulin (Tg) might be a more sensitive biomarker of the long-term maternal iodine status.Aim: To study whether maternal Tg is associated with maternal and newborn thyroid hormone conce...

Purpose: Although the majority of differentiated thyroid cancer (DTC) patients have favorable outcome, approximately up to 20% of them may develop metastatic and/or locoregional disease persistence. One-third of those patients may not respond to the treatment with radioiodine (RAI refractory DTC, RAI-R DTC). There are few reports of real-life experience concerning the clinical course and the treatment modalities that have been used in patients with RAI-R DTC.<p class="abst...

Introduction: Resistance to thyroid hormone beta (RTHβ) is a rare genetic disorder characterized by impaired responsiveness to thyroid hormone in tissues expressing TRβ. This case report explores the clinical manifestation of RTHβ in a 15-year-old male presenting with acute and intensive chest pain and subsequent diagnostic challenges.Case Report: At midnight, a 15-year-old male reported acute, sharp chest pain, prompting medical attention...