Endocrine Abstracts

Context: Pheochromocytomas and paragangliomas (PPGLs) are rare tumours with potentially harmful cardiovascular complications. Traditionally, they were detected in patients with symptoms and signs of catecholamine excess or during genetic surveillance. However, according to recent reports, PPGLs are increasingly being diagnosed in the setting of incidentally discovered adrenal masses.Aim: To assess the initial clinical presentation of our PPGL patients wi...

Context: The role for hormone parameters at adrenal venous sampling (AVS) in predicting clinical and biochemical outcome remains controversial.Objective: To investigate the impact of hormone parameters at AVS under cosyntropin stimulation on lateralization and on complete biochemical and clinical outcome.Methods: We retrospectively evaluated 168 sequential AVS under cosyntropin infusion. Bilateral successful cannulation rate was 83...

Introduction: Bilateral macronodular adrenocortical disease (BMAD) is an adrenal cause of Cushing’s syndrome explained in a subset of patients by inactivation of the tumor suppressor genes ARMC5 or KDM1A. Genetic and transcriptomic studies cluster BMAD in 3 distinct molecular groups: one with ARMC5 inactivation, one with KDM1A inactivation and a third group with no known genetic cause. Although ARMC5 and KDM1A are invo...

Background: Hypertension affects more than 30% of the adult population worldwide and is a major cardiovascular risk factor. Identifying secondary causes of hypertension is key to offering targeted treatments and mitigating adverse health outcomes. We tested the performance of urine steroid metabolomics (USM), the computational analysis of 24-hour urine steroid metabolome data by machine learning, for diagnosing endocrine forms of hypertension.Methods: 14...

Introduction: Pharmacological glucocorticoid (GC) treatment may cause iatrogenic adrenal insufficiency (GIA), although the prevalence and clinical implications are debated. With 3% of the Danish population redeeming prescriptions of systemic GC annually, the number of patients at risk is potentially extensive. Taken together, there is an unmet need for a prospective and unbiased assessment of the GIA prevalence.Materials and Methods: The data for this re...

Primary aldosteronism (PA) is the most frequent form of secondary hypertension and is due to autonomous aldosterone production by the adrenal gland. During the last decades, major advances have been made in our understanding of the disease with the identification of germline or somatic mutations in ion channels and pumps. These mutations enhance calcium signaling, the main trigger of aldosterone biosynthesis. The objective of our work was to elucidate, using chemogenetic tools...

Background: Adrenal Incidentaloma’s (AI) incidence has been increased 10-fold in the past two decades and more specifically, up to 7% in the general population and up to 9% in elderly patients. Determining whether an adrenal mass is malignant or hormonally active is of great clinical and socioeconomical importance, in order to select the best medical approach and follow up. Artificial Intelligence techniques could provide useful clinical tools for predicting the nature of...