Endocrine Abstracts

Purpose: Some countries have introduced legislation to regulate medical practices regarding DSD. We performed an international comparative law study to better understand how to integrate our medical decisions into these regulations.Material and Methods: With an international medical law research unit 1- we extracted legislative texts, decrees, ministerial recommendations from different countries 2- we sent a questionnaire to surgeons caring for DSD-child...

Objective: Obesity and polycystic ovary syndrome (PCOS) affect endomertial receptivity and may cause implantation failure, defective placentation, and pregnancy loss. Glucagon-like peptide-1 (GLP-1) receptor agonist (RA) improved the endometrial function in animal models, presumably by anti-inflammatory action and reduction of endometrial fibrosis. The impact of GLP-1RA on human endometrioum has not yet been investigated.Aim: We compared endometrial tran...

Primary ovarian insufficiency (POI) affects 1% of women before age 40 years, and in 70-90% of cases is defined as idiopathic. Although numerous POI-associated genes have been identified in recent years, the prevalence and pathogenicity of individual rare gene variants is still difficult to establish. The aim of our study was to retrospectively analyze the correlation between genotype and phenotype in patients with idiopathic POI, providing a more detailed characterization of P...

Mutations in the genes of PROK2/R2 cause isolated hypogonadotropic hypogonadism (IHH) in humans, and defects in the PROK2/R2 pathway metabolic disturbances in mice. The role of naturally occuring mutations in the reproductive and metabolic health of the general population remains unknown. We hypothesized that individuals with naturally occurring rare PROK/R2 variants will display dysregulation of their reproductive and metabolic fitness. We ...

Puberty is a key maturational process that culminates with the acquisition of reproductive capacity. This event demands significant energy resources to support the profound biological changes that occur during this period, including the activation of the reproductive axis. To this end, a plethora of signals operate for transmitting metabolic information to the reproductive axis in order to precisely regulate pubertal awakening depending on energy availability. Among others, gh...

Introduction: Autoimmunity is an important etiological factor of premature ovarian insufficiency (POI, menopause <40 years). It has been estimated that 4-50 % of POI cases are of autoimmune origin. Only a few studies, with sample sizes of dozens to hundreds POI cases, have investigated the prevalence of autoimmune diseases in women with POI. We aimed to assess in an essentially larger data set the prevalence of severe autoimmune diseases treated in tertiary care prior to P...

Background: PCOS is characterised by increased production of ovarian and adrenal androgens. Obesity is closely connected to excess androgens and to the disruption of hormone circadian rhythmicity. To date, it is not clear whether hyperandrogenism in PCOS, complicated or not by obesity, is associated with androgen rhythm dysregulation.Aim: To investigate androgen diurnal rhythmicity and overall daily androgen exposure by measuring testosterone(T), androst...