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Endocrine Abstracts (2024) 99 P329 | DOI: 10.1530/endoabs.99.P329

ECE2024 Poster Presentations Pituitary and Neuroendocrinology (120 abstracts)

Daytime sleepiness and health-related quality of life in patients with childhood-onset craniopharyngioma

Laura Verena Mann-Markutzyk 1 , Julia Beckhaus 1,2 , Jale Oezyurt 3 , Carsten Friedrich 1 & Hermann Müller 1


1University Children’s Hospital, Carl von Ossietzky Universität Oldenburg, Department of Pediatrics and Pediatric Hematology / Oncology, Klinikum Oldenburg AöR, Oldenburg, Germany; 2Carl von Ossietzky Universität Oldenburg School VI - School of Medicine and Health Sciences, Division of Epidemiology and Biometry, Oldenburg, Germany; 3Carl von Ossietzky Universität Oldenburg School IV - School of Medicine and Health Sciences, Biological Psychology Lab, Department of Psychology, Oldenburg, Germany


Background: Adamantinomatous craniopharyngioma (CP) is a rare embryonal malformation originating from remnants of the craniopharyngeal duct and located in the sellar and/or parasellar area. Overall survival rates are high (92%), but frequently quality of life (QoL) is severely impaired in patients with CP involving hypothalamic structures. Tumor- and/or treatment-related hypothalamic lesions result in disturbances of circadian rhythms including increased daytime sleepiness.

Patients and Methods: After a median follow-up interval of 10 years (range: 1-39 years), 119 patients (63 female / 56 male) with CP, recruited in KRANIOPHARyNGEOM 2000/2007 and KRANIOPHARyNGEOM Registry 2019 between 2000 and 2022, were analysed for daytime sleepiness by Epworth scale (ES) and for QoL by EORTC QLQ-C30 questionnaire.

Results: CP patients (n= 85) with pathologically increased ES score (ES score > 12) had worse QoL (P= 0.003), when compared with CP patients with normal ES score (n= 34). Pathologically increased daytime sleepiness (ES score) was negatively correlated with QoL (r= -0.395; P< 0.001). Surgical hypothalamic lesions (71% of patients) were associated with higher ES scores, wheras such impact could not be observed for presurgical hypothalamic involment of CP (73% of patients).

Conclusion: As increased daytime sleepiness plays an important role for QoL in survivors of CP, treatment of disturbances of circadian rhythms with medication such as central stimulating agents is recommended. For prevention of increased daytime sleepiness, hypothalamus-sparing surgical treatment startegies should be considered as state of the art in patients with CP.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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