Endocrine Abstracts

Background: Diabetes and renal disease are global burden with increasing prevalence, respectively. Moreover, they are closely related because diabetic nephropathy itself is well known serious complication of diabetes. However, the significance of decreasing fasting blood glucose on the risk of renal complications remains unclear. We identified the effect of chanes in fasting serum glucose level without diabetes mellitus on the renal complication in Korean adults.

Methods: We analyzed the data from retrospective cohort of Korean National Health Insurance Service-Health Screening (NHIS-HealS). In total, 267.176 Korean adults aged over 40 years measured change in serum fasting glucose level without diabetes at baseline according to the criteria of impaired and diabetic fasting glucose status: normal fasting glucose (NFG, fasting glucose: <100 mg/dl), impaired fasting glucose (IFG, fasting glucose: 100.0–125.9 mg/dl), and diabetic fasting glucose (DFG, fasting glucose: ≥126.0 mg/dl). ComparedCox proportional hazard regression model was used to obtain the hazards ratio (HR) with 95% confidence interval (CI) for the incidence of CKD and ESRD. Individuals, selected among national health examination participants in first in 2002–2003 and second in 2004–2005, underwent follow-up evaluations until 2019.

Results: In this report, we describe the protective effect of early glucose recovery on the risk of CKD and ESRD development. In comparison with participants with persistant DFG, participants with recovery from DFG to NFG had an decreased risk of CKD(HR [95% CI]: 0.76 [0.59-0.97], P=0.025) and ESRD(HR [95% CI]: 0.64 [0.39-1.07], P=0.089).

Conclusions: Early recovery of NFG in individuals with DFG is associated with decreased risk of development of Chronic Kidney Disease and End Stage Renal Disease.