Endocrine Abstracts

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies indicate that PFAS may disrupt androgenic and estrogenic pathways, potentially affecting fetal development. During 1st trimester, concentrations of sex hormone-binding globulin (SHBG) increase due to higher estrogen levels from the placenta. The increment of SHBG concentration results in a compensatory increase in t...

Objectives: Recent evidence suggest that environmental pollution may be involved in the worldwide increase of thyroid cancer (TC) incidence occurred over the last few decades. Indeed, some environmental pollutants, namely endocrine disruptive chemicals (EDCs), have been linked to endocrine system disruption, including thyroid dysfunction, and increased risk of TC. Several EDCs are known to be Persistent Organic Pollutants (POPs) due to their long half-life in the environment, ...

Background: As persistant organic pollutants, polychlorinated biphenyls (PCBs) are widespread in environment worldwide. Serum PCBs and nuclear factor erythroid 2-related factor 2 (NRF2) are associated with glucose homeostasis damage in the general population. However, there is a lack of epidemiological evidence on the interaction between serum PCBs and NRF2 gene in relation to glucose homeostasis damage.Objectives: We aimed to explore the intera...

Endocrine-disrupting chemicals, including bisphenol A (BPA) may promote obesity. The role of 1,25-Dihydroxyvitamin D3 (VitD) in counteracting adipogenesis is still a matter of question. Thus, the current study aims to investigate whether and how VitD exposure during adipogenesis could prevent the BPA pro-adipogenic effect in adipocyte models: the mouse pre-adipocytes 3T3-L1 and the human adipose-derived mesenchymal stem cells (hAMSC). 3T3-L1 and hAMSC were treated with VitD (1...

Background: Styrene and ethylbenzene (S/EB), the monomers found in polystyrene (PS) and polyethylene (PE), are known to continuously leach into the environment and food products. The prevalent use of hand sanitizers containing S/EB during the COVID-19 pandemic has heightened concerns about the health implications of S/EB exposure. Notably, the impact of S/EB exposure on the risk of type 2 diabetes mellitus (T2DM) and its interaction with genetic factors in the general populati...

Background: Active smoking has been associated with alterations of the hypothalamic-pituitary-adrenal axis. A role in the pathogenesis of adrenal tumors has also been proposed previously. No data investigating the relationship between smoking and hormonal secretion of adrenal tumors are yet available.Aim: To investigate the association between smoking habit with morphology and hormonal pattern of adrenal tumors.Methods: We retrospe...