Endocrine Abstracts

Background/Introduction: Today, GLP-1 receptor agonists have great clinical importance in the treatment of type 2 diabetes and obesity. Beside their known mechanisms to lower blood sugar and enhance satiety signals, GLP-1 also seems to play a significant role in sodium and water balance. This can be supported by the finding of GLP-1 receptor expression in various locations of the kidney, the enteric system and key brain structures. Recent findings investigating long-term effec...

Pituitary tumours (PTs) constitute approximately 15% of all brain tumours, affecting up to 5% of the general population. The majority of PTs are hormonally active tumours (approximately 70%), resulting in significant comorbidities associated with hormone release. Furthermore, clinically non-functioning PTs (NFPTs, around 30%) exhibit mass effect-related comorbidities due to delayed diagnosis, despite lacking a link to hormone excess. Recent studies indicate that aberrant alter...

Pituitary neuroendocrine tumors (PitNETs) are typically benign tumors presenting with symptoms related to hormone hypersecretion and/or intracranial mass. Current classification of PitNETs is based on the immunohistochemical expression of adenohypophysial hormones and three main pituitary-specific transcriptions factors PIT1, TPIT and SF1. PitNETs usually remain intrasellar, however, 20-40% of tumors show invasiveness into cavernous sinus and 6–8% infiltrate into the bone...

Background: While gonadotroph tumors are lacking both medical treatment options and prognostic markers, the tumor microenvironment represents a promising tool. The aim of this study was to 1) identify new tumor microenvironment actors in gonadotroph tumors, 2) gain insight into the tumorigenesis mechanisms driven by these tumor microenvironment cells, and 3) identify new tumor microenvironment-related prognostic markers, as well as new therapeutic targets.<p class="abstext...

Background: Papillary craniopharyngiomas (PCPs) are driven by V600E BRAF mutations in 95% of cases. Recently, combined anti-BRAF/MEK targeted therapy (TT) has emerged as a potential treatment in aggressive PCPs. However, standardized data on large cohorts are still lacking. Our study aimed to assess the real-life efficacy and safety of TT in patients with PCPs.Methods: This was a retrospective national multicenter study involving patients with V600E BRAF...

Background: Due to the rarity and the slow progress of the disease, there is a considerable diagnostic delay in acromegaly, contributing to increased morbidity and mortality. Voice analysis may decrease this delay as patients with acromegaly often develop a dark voice and unclear speech due to macroglossia, enlarged lips and edema in the pharynx and larynx. Modern technology offers higher speed and power of voice analysis and increased the interest in voice as a biomarker to i...