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Endocrine Abstracts (2024) 99 OC4.1 | DOI: 10.1530/endoabs.99.OC4.1

ECE2024 Oral Communications Oral Communications 4: Diabetes, Obesity, Metabolism and Nutrition | Part I (6 abstracts)

Glucose-loaded dopamine transporter is associated with mood altering effect of sweet foods and control over eating sweets

Kyoungjune Pak 1 , Jihyun Kim 1 , Keunyoung Kim 1 , Seongho Seo 2 & Myung Jun Lee 1


1Pusan National University Hospital; 2Pai Chai University


Introduction: Craving for sweet taste is innate, and spans all ages in humans. The hedonic response to sweet taste predicts the future weight gain in humans. In this study, we investigated the association of sweet taste questionnaires (STQ) with dopamine transporter and brain glucose uptake.

Methods: Thirty-five healthy, nonobese male subjects were enrolled in this study. Each subject visited the institution three times, on separate days, for three brain PET scans (two18 F-FP-CIT PET scans and one18 F-FDG PET scan). Dynamic18 F-FP-CIT PET scans were acquired 10 mins after injection of either glucose (300 mg/kg) or placebo. Static 18 F-FDG PET scans were acquired 60 mins after injection of18 F-FDG. For18 F-FP-CIT PET, dopamine transporter (DAT) availability, expressed in terms of binding potential (BPND), were measured by analyzing time-activity curve via the simplified reference tissue method. For18 F-FDG PET, the mean uptake of each striatal region-of-interest was scaled to the mean of global cortical uptake of each individual, and defined as standardized uptake value ratio (SUVR). Also, subjects were assessed with 12-item self-reporting Sweet Taste Questionnaire (STQ) with 2 factors; STQ 1: sensitivity to the mood altering effect of sweets, and STQ 2: impaired control over eating sweet foods. The effects of STQ on striatal BPNDand SUVR were investigated using Bayesian hierarchical modelling. We created models separately with STQ 1, and STQ 2 as predictors, with striatal BPND and SUVR as a dependent variable, adjusting for age.

Results: Thirty-five subjects (age 24.4±2.7 years, BMI 23.8±3.4 kg/m2) underwent two18 F-FP-CIT brain PET scans, and twenty-four underwent additional18 F-FDG brain PET scans. STQ 1 (sensitivity to the mood altering effect of sweets) ranged from 7 to 28 with the mean of 14.9±5.9. STQ 2 (impaired control over eating sweet foods) ranged from 5 to 19 with the mean of 9.1±4.3. Glucose-loaded DAT availability was negatively associated with STQ 1 (sensitivity to the mood altering effect of sweets), and positively with STQ 2 (impaired control over eating sweet foods). However, the effects of STQ 1 and STQ 2 on placebo-loaded DAT availability and brain glucose uptake markedly overlapped with zero.

Conclusion: Glucose-loaded dopamine transporter is associated with mood altering effect of sweet foods and control over eating sweets. The change of dopamine transporter after glucose loading may be the key role for the craving for the sweet foods.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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