Endocrine Abstracts

Introduction: Craving for sweet taste is innate, and spans all ages in humans. The hedonic response to sweet taste predicts the future weight gain in humans. In this study, we investigated the association of sweet taste questionnaires (STQ) with dopamine transporter and brain glucose uptake.Methods: Thirty-five healthy, nonobese male subjects were enrolled in this study. Each subject visited the institution three times, on separate days, for three brain ...

Introduction: Hyperglycaemia has been associated with worse maternal and foetal outcomes as well as higher risk for future type 2 diabetes (T2D).Objectives: We study the association between glucose above diagnostic threshold (GADT) at gestational diabetes (GD) diagnosis and risk of perinatal complications and maternal glucose abnormalities at post-partum.Materials and Methods: Retrospective study based on the national register of G...

Introduction: The risk of cardiovascular disease (CVD) is increased in type 1 diabetes (T1D). Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to CVD, but evidence hereof is limited in people with T1D. Endothelial dysfunction is currently considered a key early event in the atherosclerotic process, but is never determined in people with T1D and co-existent MASLD.Methods: We measured flow-mediated dilation (FMD) and nitrate-media...

Recent years have demonstrated increasing focus on augmenting secretion of glucagon-like peptide (GLP)-1 from intestinal L cells, to improve the treatment and/or prevention of obesity and type 2 diabetes. However, finding strong stimuli and identifying novel compounds has proven difficult. To discover new GLP-1 secretagogues, we gave 49 individuals (76% female, BMI 28.3±4.8 kg/m2) a high-fat liquid mixed meal (250 mL Nutridrink, Nutricia®). Plasma samples,...

Background: Severe hypoglycemia, marked by blood glucose levels below 3 mmol/l (level 2) or necessitating third-party assistance (level 3), poses a significant risk leading to unplanned hospital admissions in individuals with diabetes. However, there is a paucity of information on admitted patients’ characteristics, management, and outcomes.Objective: To explore the characteristics of the population, precipitating factors and outcomes of people admi...

Background: Obesity, as a worldwide healthcare problem, has been attracting more and more attention. Chronic low-grade inflammation is regarded as an inducer of adipocyte cell death. Pyroptosis,a kind of inflammatory cell death,is involved in various inflammatory diseases.Gasdermin E(GSDME) is a mediator of pyroptosis via the cleavage of caspase-3. However, whether GSDME is involved in the regulation of adipose tissue function remains unknown. In the present study, we aim to i...