Endocrine Abstracts

Background: Treatment resistance in prostate cancer can be the result of multiple different tumour cell adaptations generating castration-resistant prostate cancer (CRPC). Despite advancements in treatment, CRPC remains a highly lethal disease. Some CRPCs become AR independent with loss of AR expression and lineage plasticity, urgently requiring novel therapeutic strategies. BCL2 can be upregulated in some CRPCs and may be a therapeutic target for this disease subset.<p cl...

Background and Aim: Humanin is a mitochondria-derived peptide (MDP) secreted in response to oxidative stress and linked to diverse cellular processes including inflammation and insulin resistance. Humanin has been shown to be downregulated in polycystic ovaries and exogenous humanin supplementation has attenuated insulin resistance and ovarian morphological abnormalities in a PCOS rat model. The aim of this study was to investigate the role of humanin in the pathophysiology of...

Background: Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, with a globally increasing incidence that significantly affects maternal and infant health. Currently, there is a lack of effective early diagnostic markers for GDM. Therefore, it is necessary to identify diagnostic biomarkers for early screening of GDM during pregnancy. Circular RNA (CircRNA) has been found to be a structurally unique non-coding RNA, more stable than line...

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the formation of amyloid-β (Aβ) plaques and Tau neurofibrillary tangles, leading to neuronal loss, inflammation, reduced neurogenesis, and cognitive impairment. Currently, there is no effective cure for AD, highlighting the urgent need for novel therapeutic strategies. Growth hormone-releasing hormone (GHRH), besides promoting the release of pituitary growth hormone (GH), exerts many perip...

Introduction: Hypoparathyroidism can occur post-surgically after thyroid or parathyroid surgery or in autoimmune or genetic diseases. Over several decades, the management of hypoparathyroidism included only supplementation with calcium, vitamin D3 (cholecaliferol), as well as active 1,25-dihydroxyvitamin D (calcitriol). In cases with severe hypoparathyroidism, this treatment can be limited by hypercalciuria, and these patients often need substitution with recombinant parathyro...

Brown adipocytes dissipate energy through the production of heat, acting as a defense against cold and obesity, and secrete batokines, that positively regulate metabolic functions. Thus, identifying brown-promoting molecules is crucial for developing novel therapeutic strategies against obesity and metabolic disorders. Of note, differentiation into myoblasts and later myocytes of myogenic factor 5 (Myf5) positive progenitors, the same from which brown adipocytes originate, is ...