Endocrine Abstracts

Monogenic obesity in humans is caused by loss-of-function mutations in several genes, all of which reside in the CNS, and many of which are involved in either leptin signaling or the downstream melanocortin pathway. Ablation of the CNS-specific orphan GPCR Gpr45 in mice is associated with significant monogenic obesity. However, to date, there are no associations between the loss of GPR45 and obesity in human genetics. To that end, we made our own line of Gpr45-/- mice and foun...

Background: The incidence of type 2 Diabetes Mellitus (T2D) is increasing worldwide. Prevention is possible by changing lifestyle but it’s not effective alone in real life, due to poor compliance over time. New strategies are necessary, mostly for high-risk individuals. Therapeutic microbiology is a further proposed target, and butyrate-producing bacteria can improve metabolic parameters in obese patients. Our study aims to evaluate the effect of Intestinimonas butyri...

Overview: Non-alcoholic fatty liver disease (NAFLD) is defined as a chronic increase in intrahepatic lipids (IHL). A surplus of IHL can be compensated through increased lipid export via very-low density lipoprotein (VLDL) particles. Growth hormone (GH) is known to reduce visceral and ectopic fat. However, the main pathways responsible for the in-vivo decrease of IHL under the influence of GH are yet to be determined.Methods: We assessed hepatic lipid met...

Background: Although SGLT2 inhibitors (SGLT2-i) have revolutionised the management of diabetes, they are associated with an increased risk of developing diabetic ketoacidosis (DKA). However, there remains a paucity of evidence about the risk factors, management, and outcomes of DKA episodes associated with SGLT2-i therapy. Improved understanding of these factors in order to optimise education, minimise risk, and improve outcomes of DKA episodes in individuals receiving SGLT2-i...

Objective: Diabetes and obesity cause functional hypogonadism (FH) and impair sperm quality. Testosterone replacement therapy (TRT) improves the signs and symptoms of FH but it further deteriorates sperm quality by inhibiting the endogenous gonadal axis. The effect of glucagon-like peptide-1 receptor agonists (GLP-1-RAs) on FH is suggested to be beneficial due to weight loss. However, the effect of GLP-1 RAs on sperm quality in patients with type 2 diabetes mellitus and obesit...

Background: Probiotics have beneficial effect on obesity/type 2 diabetes (T2D) related disorders in both animal models and clinical trials, at the same time, some scientific papers question the effectiveness and the safety of probiotics. In turn, postbiotics are preparations of inanimate microorganisms and / or their components, which are directly identified with the safety of their use and the health benefits of the host.Aim: To conduct placebo-controll...