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Endocrine Abstracts (2024) 99 EP180 | DOI: 10.1530/endoabs.99.EP180

ECE2024 Eposter Presentations Thyroid (198 abstracts)

Autoimmune thyroid disease as a risk factor of atherosclerosis

Tamuna Gvianishvili 1 , 2 & Maia Kapanadze 2 & 3


1Ivane Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia; 2Tbilisi State Medical University, Tbilisi, Georgia; 3Academician O. Gudushauri National Medical Center, Tbilisi, Georgia


The relationship between subclinical hypothyroidism (SH) and Atherosclerotic (At) cardiovascular diseases (CVD) has been one of the most popular and discussing topics, because the existence of a causal relationship between Hashimoto’s thyroiditis (HT), the lipid profile, and the molecular biology of the follicular epithelium has not been conclusively established. We investigated 59 patients (female), which had undergone total thyroidectomy, lobectomy. Patients were divided into 3 groups: group I – HT (n=22), group II – HT with At (n=12), group III – At (n=25). Thyroid function and lipid profile were determined by international guidelines of laboratory tests, coronary and femoral arteries intima-media thickness (IMT) - high-resolution ultrasonography, histological (H&E) and immunohistochemical markers were used: transcriptional protein p63 and neuroectodermal marker protein S100. The obtained results showed that: dyslipidemia and the diastolic hypertension accelerate the hypothyroidism in II group (HT with At) by predisposing carotid and femoral arteries IMT. FT4 is related to clinical features of atherosclerosis, THS and anti-TPO antibody levels are directly linked to the cardiovascular disease complications (myocardial infarction and hypertension). Biomarkers S100 and p63 data revealed a direct negative correlation between hypercholesterolemia and high morphological risks of Hashimoto’s parenchyma changes. Namely, the trend of follicular epithelial dysplasia changes in the form of remodeling of parenchyma stem cells was revealed.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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