ECE2024 Eposter Presentations Thyroid (198 abstracts)
A spontaneous remission of Hashimoto’s thyroiditis
Oumeyma Trimeche 1 , Bilel Ben Amor 1 , Ekram Hajji 1 , Matiem Souissi 1 , Ines Bayar 1 , Sana Abid 1 , Héla Marmouch 1 , Hanene Sayadi 1 & Inès Khochteli 1
1Fattouma Bourguiba University hospital, Monastir, Tunisia
Introduction: Hashimoto’s thyroiditis (HT) is one of the most frequent endocrine diseases worldwide that is typically irreversible. Herein we report the case of a woman who had spontaneous remission of hypothyroidism while discussing the potential mechanisms underlying this unusual evolution.
Case report: T.C. is a 44-year-old woman with no familial history of thyroid diseases nor auto-immune conditions. She has no particular personal medical history. She consulted our Endocrinology department the first time in September 2021, with clinical signs suggestive of hypothyroidism such as asthenia, chronic constipation, myxedema and alopecia. Hormonal evaluation confirmed the diagnosis of primary hypothyroidism: elevated Thyroid stimulating hormone (TSH=206 µui/ml) and low thyroxine (FT4=2.29 pmol/l). Thus, she was put on 100 µg per day of Levothyroxine. Her cervical echography showed hypotrophic gland with normal vascularization. Her anti thyroperoxidase antibodies were elevated 120 ui/ml (normal <50) as well as her anti TSH receptor antibodies >40 UI/l (normal <1.8). She initially reported resolution of her symptoms. Shortly after, her TSH began to fall. As a result, her levothyroxine dose was diminished until completely stopping it after two years. On last check up, she was asymptomatic, had a TSH of 0.14 µui/ml and an FT4 of 10.3 pmol/l. Intriguingly, her anti TSH receptor became negative. Ultrasound was normal at last control.
Discussion: There are some hypotheses that can explain this intriguing phenomenon: cessation of medications susceptible of inducing hypothyroidism, high iodine exposure and disappearance of blocking anti TSH receptor antibodies, which in our case seems the most plausible cause.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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