ECE2024 Eposter Presentations Reproductive and Developmental Endocrinology (78 abstracts)
Body composition influences on serum anti-müllerian hormone (AMH) levels in adult males imply hemodilution
Veronika Tandl 1 , Christoph Haudum 1 , Katharina Eberhard 2 , Barbara Hutz 1 , Ines Foessl 1 , Ewald Kolesnik 3 , Andreas Zirlik 3 , Dirk von Lewinski 3 , Daniel Scherr 3 , Nicolas Verheyen 3 , Thomas Pieber 1 & Barbara Obermayer-Pietsch 1
1Medical University of Graz, Division of Endocrinology and Diabetology, Department of Internal Medicine, Graz, Austria; 2Medical University of Graz, Core Facility Computational Bioanalytics, Graz, Austria; 3Medical University of Graz, Department of Internal Medicine and University Heart Center Graz, Graz, Austria
Background: A negative relationship between body mass index (BMI) and serum Anti-Müllerian hormone (AMH) levels has been previously reported. Whether this is because of an adverse effect of adiposity on AMH production or the hormone’s dilution in a higher blood volume that accompanies larger body size (‘hemodilution’) is not yet clear. Blood volume can be estimated by body weight, body surface area (BSA) or lean mass (LM). Of note, adipose tissue is poorly perfused and adds relatively little to the overall blood volume.
Objectives: To investigate a possible hemodilution effect, we analyzed the relationships between serum AMH levels and different body size and composition parameters in adult males.
Methods: We used data of 382 adult, male participants of the ongoing, prospective BioPersMed study cohort. Body parameters used include height, weight, waist circumference, BMI, waist-to-hip ratio, body surface area (BSA) and estimated lean mass (eLM). Of 278 participants, dual energy X-ray absorptiometry (DXA)-derived body composition data, including fat mass (FM) and LM, were additionally available. We performed univariate and multivariate regression models with potential confounders (age, follicle-stimulating hormone, and estradiol) included as additional predictors.
Results: In the fully adjusted models, weight (R2=0.201; β=-0.002; P=0.0022), BSA (R2=0.206; β=-0.231; P=0.0006) eLM (R2=0.206; β=-0.006; P=0.0006) and LM (R2=0.197; β=-0.006; P=0.003) significantly predicted AMH. In an age adjusted model that challenged FM and LM against each other by including them both as predictors, only LM remained significant (R2=0.061; β=-0.007; P=0.0035).
Conclusions: In adult males, weight, BSA, eLM and LM (proxies of blood volume) better predicted serum AMH levels than measures of adiposity – suggesting hemodilution is at least partly responsible for the observed inverse relationship between AMH concentrations and BMI. Thus, hemodilution should be considered for normalization in future studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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