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Endocrine Abstracts (2024) 99 EP1189 | DOI: 10.1530/endoabs.99.EP1189

1Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medecine and Pharmacy, University of Mohammed 1st, Oujda, Morocco, oujda, Morocco; 2Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medecine and Pharmacy, University of Mohammed 1st, Oujda, Morocco, Laboratory of Epidemiology, Clinical Research and Public Health, Mohammed VI University Hospital Center, Faculty of Medecine and Pharmacy, University of Mohammed 1st, Oujda, Morocco, Oujda, Morocco


Introduction: Precocious puberty results from the premature activation of the gonadal axis. It mimics physiological pubertal development, although at an inappropriate chronological age (before 8 years in girls and 9 years in boys). It is a serious challenge with repercussions on physical and psychosocial development. We aimed to evaluate the different etiology of Precocious puberty and the effectiveness of the Gonadotropin-releasing hormone (GnRH ) agonists.

Patients and methods: This is a retrospective, descriptive study including a total of thirty-four children with precocious puberty follow-up in the Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital, Oujda, Morocco. A clinical examination, statural evaluatiol and hormonal settings were performed in all cases. Statistical analysis was performed using SPSS version 21.

Results: The average age of our study group in the first consultation was 5,77±2,28 years. Thirty one girls and 3 boys. Sixty-five percent of the patients were consulted in the first year of evoluation. The most common consultation reason was breast development (35%), followed by pubic hair develpement (27%). Statural advancement was found in 47%, with a bone age differance more than 2 years in 35%. LHRH testing was carried out in 83% of patients. Central precocious puberty was predominant with 24%. Fourty-four percent of our patients were treated with agonists GnRH. Post-treatment evaluation revealed that 73% of des patients presented stability or regression of signs.

Discussion and conclusion: Early diagnosis of precocius puberty can prevent short stature in adulthood. LHRH testing is the key test to. Treatment by GnRH agonists has demonstrated efficacy in central precocious puberty.

References: 1. Latronico, A. C., Brito, V. N., & Carel, J.-C. (2016). Causes, diagnosis, and treatment of central precocious puberty. The Lancet Diabetes & Endocrinology, 4(3), 265–274. 2. Carel, J.-C. (2005). Le traitement des pubertés précoces par agonistes de la GnRH. Annales d’Urologie, 39, S85–S88. 3. Kim HK, Kee SJ, Seo JY, Yang EM, Chae HJ, Kim CJ. Gonadotropin-releasing hormone stimulation test for precocious puberty. Korean J Lab Med. 2011 Oct;31(4):244-9.

Key words: Precocious puberty – agonistes GnRH

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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