ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)
Measurement of visceral fat area in women with hypopituitarism receiving conventional hormone replacement therapy: a case-control study
Salma Salhi 1 , Ibtissem Oueslati 1 , Seif Boukriba 2 , Elyes Kamoun 1 , Meriem Yazidi 1 , Nadia Khessairi 1 , Fatma Chaker 1 , Habiba Mizouni 2 & Melika Chihaoui 1
1La Rabta University Hospital, Department of Endocrinology, Tunis, Tunisia;2La Rabta University Hospital, Department of Radiology, Tunis, Tunisia
Introduction: Visceral fat area (VFA) represents the amount of fat stored in the abdominal cavity around internal organs. It is increasingly recognized as a crucial marker of metabolic health and cardiovascular risk. The aims of the present study were to measure VFA and to assess its associated factors in women with complete anterior hypopituitarism.
Methods: We conducted a cross-sectional study including 50 patients with a complete anterior hypopituitarism secondary to Sheehan syndrome, receiving conventional hormone replacement therapy, and 50 age and body-mass index (BMI)-matched controls. Participants had a clinical examination, laboratory tests and an abdominal computed tomography scan to calculate the VFA.
Results: The mean age was 62.2±9.4 years in the patients and 60.6±8.4 years in controls (P=0.385). The mean BMI was 29.6±6.0 kg/m2 in patients and 30.0±5.0 kg/m2 in controls (P=0.741). Patients had a significantly higher waist circumference than controls (respectively: 101.3±10.2 cm vs 95.7±10.5 cm; P=0.007). Parietal fat area was comparable between the two groups (patients: 270.2±97.7 cm2; controls: 242.7±107.3 cm2; P=0.154). However, VFA was significantly higher in patients (170.6±58.8 cm2) than in controls (148.8±73.8 cm2) (P=0.030). Visceral adiposity, defined by a VFA ≥ 150 cm2, was observed in 64% of patients and 39% of controls (P=0.014). Sheehan syndrome was positively associated with visceral adiposity (Odds Ratio=2.78, 95%-Confidence interval: 1.21-6.37; P=0.014). Age (P=0.022) and sedentary (P=0.010) were associated with visceral adiposity. However, diagnostic delay, duration of the disease, family history of metabolic disorders, as well as GH and FT4 levels, and hormone replacement therapy were not associated with visceral adiposity.
Conclusions: VFA was significantly higher in women with hypopituitarism than in controls. Visceral adiposity was more prevalent in patients compared to age and BMI matched controls. Its associated factors were age and sedentary.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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