ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)
Establishment and representativeness of the stockholm sodium cohort: a laboratorial and pharmacoepidemiologic database covering 1.6 million individuals in the stockholm county
Issa Issa 1 , Buster Mannheimer 1 , Mikael Franko 1 , Jakob Skov 2 , Jonatan Lindh 3 & Henrik Falhammar 4
1Södersjukhuset, internal medicine, stockholm, Sweden; 2Karlstad University Sweden; 3Tandvårds- & läkemedelsförmånsverket TLV, Sweden; 4Karolinska Institute, Sweden
Objective: Hyponatremia is associated with considerable morbidity, and mortality but causal links have been difficult to establish. Here, we describe the establishment and representativeness of the Stockholm Sodium Cohort (SSC), designed to study etiologies and outcomes of hyponatremia.
Study, Design and Setting: All residents of Stockholm County, undertaking at least one serum sodium test between 2005-2018 were included in the SSC. Individual-level test results from over 100 Laboratory parameters relevant to hyponatremia were collected and linked to data on demographics, socioeconomic status, healthcare contacts, diagnoses and dispensed prescription medications using national registers.
Results: A total of 1 632 249 individuals, corresponding to 64% of the population of Stockholm County were included in the SSC. Coverage increased with advancing age, ranging from 32% in children and adolescents (≤18 years) to 97% among the oldest (≥80 years). The coverage of SSC included the vast majority of patients in Stockholm County, diagnosed with diabetes mellitus (93%), myocardial infarction (98%), ischemic stroke (97%), cancer (85%), pneumonias requiring inpatient care (95%) and deaths (88%).
Conclusion: SSC is the first cohort specifically, designed to investigate sodium levels in a large, population-based setting. It includes a wide range of administrative health data and Laboratory analyses. The coverage is high, particularly, among elderly, and individuals with comorbidities. Consequently the cohort has a large potential for exploration of various aspects of hyponatremia.
Keywords: Dysnatremia, Stockholm, Sodium, registry SSC, hyponatremia
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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