ECE2024 Eposter Presentations Pituitary and Neuroendocrinology (214 abstracts)
Gender related metabolic differences in hypopituitarism
Dragana Miljic 1,2 , Marina Nikolic Djurovic 1,2 , Mirjana Doknic 1,2 , Sandra Djurdjevic 1,2 , Marko Stojanovic 1,2 , Zvezdana Jemuovic 1 , Ivana Cekic 1 , Ivan Jevtic 1 & Milan Petakov 1,2
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Belgrade, 11 000 Belgrade, Serbia, Neuroendocrinology; 2University of Belgrade - Faculty of Medicine
Background: Hypopituitarism is characterised by multiple pituitary hormone deficiencies causing adverse metabolic milleu and body composition changes.
Aim: Our aim was to investigate the gender related differences in the prevalence of metabolic syndrome (MetS) and metabolic profiles in patients with hypopituitarism compared to obese controls.
Patients and methods: A retrospective study of 282 patients with hypopituitarism (136 women and 146 men) age 49.2±15.1 years, and body mass index- BMI 27.9±5.8 kg/m2, has been performed. The most common cause of hypopituitarism was non-functioning pituitary tumor n=140 (49.6%). Group of 246 obese control subjects (115 females, 131 males) age 42.9±14.8 yrs BMI 30.5±5.2 kg/m2 was used for comparisson. Antropometric, metabolic and clinical parametars were collected and analyzed.
Results: MetS was diagnosed in 48.6% and 57.1% of patients with hypopituitarism using ATPIII and IDF criteria, compared to 35% and 39% prevalence in the control group (P<0.05). Prevalence was higher in female compared to male patients with hypopituitarism according to IDF (63.2 vs 51.4%, P<0.05) and ATP III criteria (54.4 vs 43.2%, P<0.05). However, male patients with hypopituitarism had significantly greater waist circumference (98.6 vs 90.9 cm, P<0.001), lower HDL cholesterol (1.17 vs 1.29 mmol/l, P<0.01) and higher fasting blood glucose (4.72 vs 4.5 mmol/l, P=0.046) than females. Compared to controls significantlly higher cholesterol and triglyceride levels, despite lower BMI and waist circumference in both sexes were found in patients with hypopituitarism (Table 1).
| PARAMETERS | MALES HYPOPIT CONTROL n=146 n=131 | FEMALES HYPOPIT CONTROL n=136 n=115 |
| BMI (kg/m2) | 28.05 31.77 P<0.01 | 27.75 29.00 P<0.01 |
| Waist circumference (cm) | 98.65 108.89 P<0.01 | 90.92 92.98 P<0.05 |
| Total cholesterol (mmol/l) | 6.67 5.59 P<0.01 | 6.73 6.12 P<0.05 |
| HDL (mmol/l) | 1.17 1.07 | 1.29 1.40 |
| LDL (mmol/l) | 4.43 3.35 P<0.01 | 4.39 3.93 P<0.01 |
| Triglyceridies(mmol/l) | 2.56 2.20 P<0.01 | 2.33 1.71 P<0.01 |
Conclusions: Female patients showed higher prevalence of MetS, while male patients with hypopituitarism had worse metabolic profiles. Compared to obese controls, hypopituitary patients had significantly worse lipid profiles and higher prevalence of MetSy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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