Graves

Karimi Meryem; Hajar Azagouagh; Hasna Ouirar; Rifai Kaoutar; Iraqi Hind; Gharbi Mohamed Elhassan

doi:10.1530/endoabs.99.EP1275

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Endocrine Abstracts (2024) 99 EP1275 | DOI: 10.1530/endoabs.99.EP1275

ECE2024 Eposter Presentations Late Breaking (127 abstracts)

Graves’ disease associated with primary biliary cholangitis: a case report

Karimi Meryem , Hajar Azagouagh , Hasna Ouirar , Rifai Kaoutar , Iraqi Hind & Mohamed Elhassan Gharbi

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Ibn Sina Rabat, Endocrinology, Rabat, Morocco

Introduction: Graves’ disease is an autoimmune thyroid disease that is frequently associated with other autoimmune diseases. In our case, we report a rare association with primary biliary cholangitis.

Case report: A 38-year-old patient, with no particular medical history, has been followed for Graves’ disease for 14 years, initially treated with carbimazole with poor therapeutic compliance and irregular follow-up. The evolution was marked by the onset of cutaneous-mucosal jaundice. Laboratory tests showed hepatic cholestasis with cytolysis and pancytopenia, persisting after discontinuation of treatment. Hepatic ultrasound was unremarkable. Liver biopsy confirmed primary biliary cholangitis. The patient was started on ursodeoxycholic acid with rapid medical preparation for definitive treatment.

Discussion and Conclusion: The disturbance of liver function tests in Graves’ disease may be correlated with thyrotoxicosis or secondary to treatment with synthetic antithyroid drugs, or it may be due to primary biliary cholangitis, which should always be considered in cases of hepatic cholestasis.