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Endocrine Abstracts (2024) 99 EP792 | DOI: 10.1530/endoabs.99.EP792

1Institute of Biophysics and Biochemistry, Mirzo Ulugbek National University of Uzbekistan, Tashkent, Uzbekistan; 2Republican Specialized Scientific Practical Medical Center of Hematology and Blood Transfusion, Uzbekistan Public Healthcare Ministry, Tashkent, Uzbekistan; 3Alfraganus University, Tashkent, Uzbekistan; 4Ya. Kh. Turakulov Center for Scientific and Clinical Study of Endocrinology, Uzbekistan Public Healthcare Ministry, Tashkent, Uzbekistan; 5Central Asian University, Tashkent, Uzbekistan


As a cytokine, TNF-α plays a role of key anti-inflammatory mediator involved in the onset and progression of insulin resistance and type 2 diabetes mellitus. TNF-α is known to inhibit insulin-stimulated of auto-phosphorylation of insulin receptors by tyrosine kinase; as the result, insulin sensitivity decreases in its turn resulting in insulin resistance and glucose transport damage. TNF-α is a trigger in the onset of obesity, diabetes mellitus and its complications. Studies on concentrations of TNF-α in peripheral blood are of high importance in assessment of extent in type 2 diabetes mellitus progression.

Materials and methods: 68 patients with type 2 diabetes mellitus, 50 persons with diabetic neuropathy of various degrees and 18 persons without any 2DM complications among them, were examined. Non-diabetics were included into the control group. ELISA was used to determine TNF-α concentrations in the blood serum of the examinees.

Results: Determination of TNF-α concentrations in blood serum of the examinees demonstrated their significant increase as compared to those in the non-diabetics (3.05±0.44 vs 1.1±0.05 pg/ml). In patients with moderate diabetic neuropathy, the serum concentrations of TNF-α turned out significantly lower than those in patients with severe disease (3.62±0.89 vs 7.13±1.14 pg/ml). Thus, paralleling disorders in carbohydrate and lipid metabolism in 2DM, concentrations of TNF-α in blood serum of the patients were found to be in direct dependence with the disease severity.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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