ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)
Prevalence and risk factors for steatosis and liver fibrosis measured by magnetic resonance elastography in adults with cystic fibrosis-related diabetes
Ana Piñar Gutiérrez , Silvia García Rey , María del Carmen Roque Cuéllar , Andrés Jiménez Sánchez , Ángeles Pizarro , Esther Quintana Gallego , Francisco Javier Castell , Manuel Romero-Gomez , Alfonso Soto & Pedro Pablo Garcia-Luna
Virgen del Rocío University Hospital, Sevilla, Spain
Introduction: Cystic fibrosis-related diabetes (CFRD) has a prevalence of 40-50% in adults. Given what we know about metabolic liver disease, studies are needed to assess whether CFRD is also related to steatosis (LS) and liver fibrosis (LF).
Objectives: To determine the prevalence of LS and LF by magnetic resonance elastography (Mre) in a cohort of adults with CFRD. Secondary: to determine the diagnostic yield of transitional elastography (Fibroscan®) and the factors associated with both entities.
Methods: Cross-sectional study of adults with CFRD in a multidisciplinary unit. Clinical evaluation, morphofunctional assessment, MRe, transitional elastography and noninvasive markers were performed. Quantitative variables are expressed as n(%); qualitative variables as P50(P25-P75). Diagnostic accuracy tests were performed. Logistic regression was performed to study risk factors.
Results: n=28. Women=15(53.6%). Age=34(28.7-40.5)years. Time of evolution=28(19.5-34)years. Malnutrition(GLIM)=15(53.6%). Exocrine pancreatic insufficiency=26(92.9%). BMI=23.2(19.7-24.5)kg/m². Insulin treatment=20(71.4%). The prevalence of LS was 25% and of LF 32.1%. In Fibroscan® it was 28.6% (71.4% sensitivity and 85.7% specificity) and 17.9% (55.5% sensitivity and 100% specificity) respectively. The AUROC of the Fibroscan® was 0.915(0.81-1) in HD and 0.936(0.838-1) in FH. We did not find any factors associated with LS. Those associated with LF are shown in the Table. Multivariate analysis could not be performed due to the low sample size.
| OR(CI 95%) | p | |
| Hemoglobin | 5.6(1.01-338.59) | 0.05 |
| Total bilirubin | 11.46(1.032-127.3) | 0.047 |
| Platelets | 0.981(0.964-0.998) | 0.031 |
| Lymphocytes | 0.038(0.002-0.615) | 0.021 |
| AST | 1.128(1.02-1.247) | 0.019 |
| Vitamin A | 0.866(0.752-0.997) | 0.046 |
| Vitamin E | 0.997(0.993-1) | 0.047 |
Conclusions: This is the first study of LS and LF in adults with CFRD performed with MRe. The prevalence was 25% and 31.1% respectively. FibroScan® demonstrated excellent diagnostic accuracy. Alterations in blood count and transaminases, as well as fat-soluble vitamin deficiencies seem to be associated with increased risk of LF.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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