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Endocrine Abstracts (2024) 99 EP65 | DOI: 10.1530/endoabs.99.EP65

Virgen del Rocío University Hospital, Sevilla, Spain


Introduction: Cystic fibrosis-related diabetes (CFRD) has a prevalence of 40-50% in adults. Given what we know about metabolic liver disease, studies are needed to assess whether CFRD is also related to steatosis (LS) and liver fibrosis (LF).

Objectives: To determine the prevalence of LS and LF by magnetic resonance elastography (Mre) in a cohort of adults with CFRD. Secondary: to determine the diagnostic yield of transitional elastography (Fibroscan®) and the factors associated with both entities.

Methods: Cross-sectional study of adults with CFRD in a multidisciplinary unit. Clinical evaluation, morphofunctional assessment, MRe, transitional elastography and noninvasive markers were performed. Quantitative variables are expressed as n(%); qualitative variables as P50(P25-P75). Diagnostic accuracy tests were performed. Logistic regression was performed to study risk factors.

Results: n=28. Women=15(53.6%). Age=34(28.7-40.5)years. Time of evolution=28(19.5-34)years. Malnutrition(GLIM)=15(53.6%). Exocrine pancreatic insufficiency=26(92.9%). BMI=23.2(19.7-24.5)kg/m². Insulin treatment=20(71.4%). The prevalence of LS was 25% and of LF 32.1%. In Fibroscan® it was 28.6% (71.4% sensitivity and 85.7% specificity) and 17.9% (55.5% sensitivity and 100% specificity) respectively. The AUROC of the Fibroscan® was 0.915(0.81-1) in HD and 0.936(0.838-1) in FH. We did not find any factors associated with LS. Those associated with LF are shown in the Table. Multivariate analysis could not be performed due to the low sample size.

OR(CI 95%)p
Hemoglobin5.6(1.01-338.59)0.05
Total bilirubin11.46(1.032-127.3)0.047
Platelets0.981(0.964-0.998)0.031
Lymphocytes0.038(0.002-0.615)0.021
AST1.128(1.02-1.247)0.019
Vitamin A0.866(0.752-0.997)0.046
Vitamin E0.997(0.993-1)0.047

Conclusions: This is the first study of LS and LF in adults with CFRD performed with MRe. The prevalence was 25% and 31.1% respectively. FibroScan® demonstrated excellent diagnostic accuracy. Alterations in blood count and transaminases, as well as fat-soluble vitamin deficiencies seem to be associated with increased risk of LF.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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