ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)
Long term use of closed-loop systems in patients with type 1 diabetes and risk of hypoglycemia
Beatriz Torres Torres 1,2 , Paloma Pérez López 1,2 , Ainhoa Alcelai Uribeecheverría 2 , Pablo Fernández Velasco 1,2 , Jaime González Gutiérrez 1,2 , Lucía Estévez Asensio 1,2 , Esther Delgado García 1,2 , Emilia Gómez Hoyos 1,2 , Gonzalo Díaz Soto 1,2 & Daniel De Luis Román 1,2
1Hospital Clínico Valladolid, Endocrinology, Valladolid, Spain; 2Facultad de Ciencias de la Salud, IEN, Valladolid, Spain
Background and Aim: Data support the use of hybrid closed-loop systems, because of it positive impact in the management of patients with type 1 diabetes (T1D). The aim was to evaluate the impact of an hybrid closed-loop system in patients with T1D at high risk of hypoglycemia.
Methods: Retrospective study of patients with T1D controlled in a Endocrinology department older than 17 years old, who were carriers of an Insulin Pump (MiniMed™640G) and Flash Glucose Monitoring System. They switched to a MiniMed™780G Hybrid closed-loop system (Medtronic), at least two years before the study. At baseline, patients had a Coefficient of Variation(CV) > 36% and/or a Time below 70 mg/dl (TBR)greater than or equal to 4%. Data of Time in Range (TIR), Time above 180 mg/dl (TAR), TBR, CV and Glucose Management Indicator(GMI) were collected at baseline and 3 months and 2 two years after change.
Results: 18 patients were included. The age was 33.5 (28-43) years old, the evolution of their T1D was on 18.6 (15-24) years and 56% were women.10 patients (55%) had an TIR >70% at baseline, compared to 100% of patients at both 3 and 24 months (P<0.001)
| TIR | TBR | TAR | CV | GMI | |
| Baseline | 68,5% (56.7-76.0) | 5% (3,5-7) | 20% (16-29) | 38.2 (33.7-41.5) | 6.6% (6.5-7) |
| 3 months | 86.3% (80.0-89.0) | 3% (2-4) | 11% (7-16) | 31.3% (27.8-34) | 6.4% (6.4-6.6) |
| 24 months | 83.1% (80-87.5) | 2% (1-4) | 14% (9.5-18.5) | 30.3% (28-33.1) | 6.6% (6.4-6.8) |
| p | <0.001 | <0.01 | <0.001 | <0.001 | ns |
Conclusions: The use of hybrid closed-loop systems, in our series, has shown an increase in TBR due to a decrease in TAR, TBR and CV. Improvement in glycometric parameters was observed at 3 months and it was maintained after 2 years of follow-up.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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