Endocrine Abstracts

Introduction: Cognitive decline is recognized as an important comorbidity of diabetes. The aim of this study was to determine the prevalence and predictive factors of cognitive decline in patients with type 2 diabetic patients.

Materials and methods: This was a prospective study including all elderly patients with type 2 diabetes aged between 45 and 75 years with a diabetes duration of more than five years, admitted to the endocrinology department Sheikh Khalifa University Hospital in Casablanca, between February and December 2022, we collected the clinical and metabolic characteristics. Cognitive decline was assessed by the Mini mental state examination and was retained if the score was less than 27.

Results: We included 152 patients. The median age was 64 years, median duration of diabetes was 15 years, 48.68% of patients had cognitive decline. In multivariate analysis, cognitive decline was significantly associated with the presence of diabetic retinopathy OR 0.00 (CI 4.85-0.09), elevated creatinine OR1.29 (CI 1.01-1.64) and the presence of dyslipidemia OR10.87 (CI 69-70.00).

Discussion: It is necessary to consider cognitive decline in diabetic patients because of its impact on disease progression and treatment compliance.