Study of the effect of obesity on degenerative complications of diabetes mellitus

Yasmine Fakhfakh; Chaima Jemai; Chaima Sdiri; Salem Dorsaf Ben; Hadhemi Belhassen; Sami Fitouri; Ali Zohra Hadj; Imen Hedfi; Olfa Lajili; Yosra Htira; Mami Faika Ben

doi:10.1530/endoabs.99.EP1176

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Endocrine Abstracts (2024) 99 EP1176 | DOI: 10.1530/endoabs.99.EP1176

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Study of the effect of obesity on degenerative complications of diabetes mellitus

Yasmine Fakhfakh , Chaima Jemai , Chaima Sdiri , Dorsaf Ben Salem , Hadhemi Belhassen , Sami Fitouri , Zohra Hadj Ali , Imen Hedfi , Olfa Lajili , Yosra Htira & Faika Ben Mami

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National Institute of Nutrition, Department C, Tunisia

Introduction: Obesity is often associated with type 2 diabetes mellitus (T2DM). We aimed to investigate associations between obesity and degenerative complications of diabetes mellitus.

Methods: This was a cross-sectional study conducted at department C of the national institute of nutrition of Tunis including patients hospitalized for uncontrolled diabetes, in November and December 2023. Demographic characteristics, anthropometric parameters, past medical history, current treatments, glycemic control, cardiovascular risk factors, diabetes-related complications and laboratory data were collected from medical records.

Results: Ninety five patients were enrolled in our study. Sex ratio was 0.34. The mean age was 53.4±18.8 years. Mean BMI was 27.2±6 kg/m²;. One quarter of the population (25.3%) had obesity. Hypertension and dyslipidemia frequencies were 48.4% and 48.4% respectively. The majority of our patients (70.5%) had type 2 diabetes. Mean duration of diabetes was 13.63±10 years. 67.4% were on insulintherpay and 87.4% had at least one degenerative complication, with a medical history of obliterating arteriopathy of the lower limbs, coronary artery disease and stroke in respectively 7.4%, 14.7% and 4.2% of cases. Mean HbA1c was 11.17±2.17%. Obesity was significantly associated to hypertension (P=0.004), dyslipidemia (P=0.03) pathologic albuminuria (P<0.001), diabetic neuropathy (P=0.01), coronary artery disease (P=0.04) and stroke (P=0.04).

Conclusion: According to our study, obesity seems to be associated with degenerative complications of diabetes mellitus. Thus, management of diabetic patients should be holistic. Reducing weight contribute to reach glycemic control and to reduce frequency and severity of chronic complications.